Allen Kelsey, Gonzalez-Olvera Rocio, Kumar Milen, Feng Ting, Pieraut Simon, Hoy Jennifer L
Department of Biology, University of Nevada, Reno, Reno, NV 89557, USA.
iScience. 2022 Oct 17;25(11):105368. doi: 10.1016/j.isci.2022.105368. eCollection 2022 Nov 18.
Integration of binocular information at the cellular level has long been studied in the mouse model to uncover the fundamental developmental mechanisms underlying mammalian vision. However, we lack an understanding of the corresponding ontogeny of visual behavior in mice that relies on binocular integration. To address this major outstanding question, we quantified the natural visually guided behavior of postnatal day 21 (P21) and adult mice using a live prey capture assay and a computerized-spontaneous perception of objects task (C-SPOT). We found a robust and specific binocular visual field processing deficit in P21 mice as compared to adults that corresponded to a selective increase in c-Fos expression in the anterior superior colliculus (SC) of the juveniles after C-SPOT. These data link a specific binocular perception deficit in developing mice to activity changes in the SC.
长期以来，人们一直在小鼠模型中研究细胞水平上的双眼信息整合，以揭示哺乳动物视觉背后的基本发育机制。然而，我们对依赖双眼整合的小鼠视觉行为的相应个体发育缺乏了解。为了解决这个主要的悬而未决的问题，我们使用活体猎物捕获试验和计算机化物体自发感知任务（C-SPOT）对出生后第21天（P21）的小鼠和成年小鼠的自然视觉引导行为进行了量化。我们发现，与成年小鼠相比，P21小鼠存在强烈且特定的双眼视野处理缺陷，这与C-SPOT后幼年小鼠上丘前部（SC）中c-Fos表达的选择性增加相对应。这些数据将发育中小鼠的特定双眼感知缺陷与上丘的活动变化联系起来。
