Miao Chao-Ying, Ye Xiao-Fei, Zhang Wei, Sheng Chang-Sheng, Huang Qi-Fang, Wang Ji-Guang
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Cardiovascular Medicine, the Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Geriatr Cardiol. 2022 Aug 28;19(8):603-609. doi: 10.11909/j.issn.1671-5411.2022.08.007.
To investigate serum triglycerides in relation to all-cause, cardiovascular, and non-cardiovascular mortality in an elderly Chinese population.
The study participants ( = 3565) were elderly (≥ 60 years) community dwellers living in a suburban town of Shanghai. Hypertriglyceridemia was defined as a serum triglycerides concentration ≥ 2.30 mmol/L (definite) and ≥ 1.70 mmol/L (borderline), respectively.
The prevalence of definite and borderline hypertriglyceridemia at baseline was 7.5% and 29.5%, respectively. It was higher in women ( = 1982, 9.0% and 33.8%, respectively) than men ( = 1583, 6.2% and 27.9%, respectively), in obese and overweight participants ( = 1566, 10.5% and 36.4%, respectively) than normal weight participants ( = 1999, 5.6% and 27.1%, respectively), and in diabetic participants ( = 177, 11.9% and 39.0%, respectively) than non-diabetic participants ( = 3388, 7.5% and 30.8%, respectively). During a median of 7.9 years follow-up, all-cause, cardiovascular and non-cardiovascular deaths occurred in 529, 216 and 313 participants, respectively. In analyses according to the quintile distributions of serum triglycerides concentration, the sex- and age-standardized mortality rate was lowest in the middle quintile for all-cause, cardiovascular and non-cardiovascular mortality (18.6, 7.8 and 11.9 per 1000 person-years, respectively, versus 21.5, 10.5 and 12.7 per 1000 person-years, respectively, in the two lower quintiles and 21.7, 9.5 and 14.0 per 1000 person-years, respectively, in the two higher quintiles). The fully adjusted hazard ratios (95% CI) for the middle quintile versus the combined two lower with two higher quintiles were 0.85 (95% CI: 0.67-1.07, = 0.17), 0.81 (95% CI: 0.54-1.19, = 0.28) and 0.87 (95% CI: 0.64-1.17, = 0.35) for all-cause, cardiovascular and non-cardiovascular mortality, respectively.
Our study showed high prevalence of hypertriglyceridemia, especially when defined as borderline and in obese and overweight participants, and mildly but non-significantly elevated risks of cardiovascular mortality relative to the middle level of serum triglycerides.
研究中国老年人群血清甘油三酯水平与全因死亡率、心血管疾病死亡率及非心血管疾病死亡率之间的关系。
研究对象（n = 3565）为居住在上海一个郊区城镇的60岁及以上老年社区居民。高甘油三酯血症分别定义为血清甘油三酯浓度≥2.30 mmol/L（确诊）和≥1.70 mmol/L（临界值）。
基线时确诊和临界高甘油三酯血症的患病率分别为7.5%和29.5%。女性（n = 1982，分别为9.0%和33.8%）高于男性（n = 1583，分别为6.2%和27.9%），肥胖和超重参与者（n = 1566，分别为10.5%和36.4%）高于正常体重参与者（n = 1999，分别为5.6%和27.1%），糖尿病参与者（n = 177，分别为11.9%和39.0%）高于非糖尿病参与者（n = 3388，分别为7.5%和30.8%）。在中位7.9年的随访期间，分别有529、216和313名参与者发生全因死亡、心血管疾病死亡和非心血管疾病死亡。根据血清甘油三酯浓度的五分位数分布进行分析，全因死亡率、心血管疾病死亡率和非心血管疾病死亡率的性别和年龄标准化死亡率在中间五分位数中最低（分别为每1000人年18.6、7.8和11.9，而在两个较低五分位数中分别为每1000人年21.5、10.5和12.7，在两个较高五分位数中分别为每1000人年21.7、9.5和14.0）。中间五分位数与两个较低五分位数和两个较高五分位数合并相比，全因死亡率、心血管疾病死亡率和非心血管疾病死亡率的完全调整风险比（95%CI）分别为0.85（95%CI：0.67 - 1.07，P = 0.17）、0.81（95%CI：0.54 - 1.19，P = 0.28）和0.87（95%CI：0.64 - 1.17，P = 0.35）。
我们的研究表明高甘油三酯血症患病率较高，尤其是在定义为临界值时以及肥胖和超重参与者中，相对于血清甘油三酯的中等水平，心血管疾病死亡率有轻度但无显著升高的风险。
