School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Clin Hypertens (Greenwich). 2024 Oct;26(10):1163-1170. doi: 10.1111/jch.14887. Epub 2024 Aug 19.
We investigated fasting hypertriglyceridemia as predictors of all-cause, cardiovascular, and non-cardiovascular mortality in an elderly male Chinese population, while accounting for various conventional cardiovascular risk factors. Our participants were elderly men recruited from residents living in a suburban town of Shanghai (≥60 years of age, n = 1583). Hypertriglyceridemia was defined as a fasting serum triglycerides concentration ≥1.70 mmol/L. Subgroup analyses were performed according to current smoking (yes vs. no), alcohol intake (yes vs. no), and the presence and absence of hypertension and hyperglycemia. During a median of 7.9 years follow-up, all-cause, cardiovascular, and non-cardiovascular deaths occurred in 279, 112, and 167 participants, respectively. After adjustment for confounding factors, fasting hypertriglyceridemia was not significantly (p ≥ .33) associated with the risk of all-cause, cardiovascular, and non-cardiovascular mortality. However, there was significant (p = .03) interaction between hypertriglyceridemia and the presence and absence of hypertension in relation to all-cause mortality. In normotensive, but not hypertensive individuals, hypertriglyceridemia was significantly associated with a higher risk of all-cause mortality (hazard ratio 1.57, 95% confidence interval 1.06-2.31). In further non-parametric analyses in normotensive individuals, the age-standardized rate for all-cause mortality increased from 18.9 in quartile 1 to 20.0, to 24.7, and to 39.9 per 1000 person-years in quartiles 2, 3, and 4 of serum triglycerides concentration, respectively (p= .0004). Similar results were observed for cardiovascular mortality. Our study in elderly male Chinese showed that fasting hypertriglyceridemia was associated with a higher risk of all-cause and cardiovascular mortality in patients with normotension but not those with hypertension.
我们研究了空腹高甘油三酯血症作为预测因素，在一个老年男性的中国人群中，包括各种传统的心血管危险因素，全因、心血管和非心血管死亡率。我们的参与者是从上海郊区城镇的居民中招募的老年人（≥60 岁，n=1583）。高甘油三酯血症定义为空腹血清甘油三酯浓度≥1.70mmol/L。根据当前吸烟（是/否）、饮酒（是/否）、高血压和高血糖的存在和不存在进行亚组分析。在中位 7.9 年的随访期间，全因、心血管和非心血管死亡分别发生在 279、112 和 167 名参与者中。在调整混杂因素后，空腹高甘油三酯血症与全因、心血管和非心血管死亡率的风险无显著相关性（p≥.33）。然而，在高血压的存在和不存在之间，高甘油三酯血症与全因死亡率之间存在显著的交互作用（p=0.03）。在血压正常但不高血压的个体中，高甘油三酯血症与全因死亡率的风险显著增加相关（危险比 1.57，95%置信区间 1.06-2.31）。在血压正常的个体中进一步进行非参数分析，全因死亡率的年龄标准化率从第 1 四分位数的 18.9/1000 人年增加到第 2、3 和 4 四分位数的 20.0、24.7 和 39.9/1000 人年，分别（p=0.0004）。心血管死亡率也观察到了类似的结果。我们在中国老年男性中的研究表明，空腹高甘油三酯血症与血压正常但不与高血压患者的全因和心血管死亡率风险增加相关。
