Sharma Vinesh, Patial Vikram
Pharmacology and Toxicology Laboratory, Dietetics & Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, HP, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, UP, India.
Front Pharmacol. 2022 Oct 21;13:991059. doi: 10.3389/fphar.2022.991059. eCollection 2022.
Kidney disease is one of the leading non-communicable diseases related to tremendous health and economic burden globally. Diabetes, hypertension, obesity and cardiovascular conditions are the major risk factors for kidney disease, followed by infections, toxicity and autoimmune causes. The peroxisome proliferator-activated receptor gamma (PPAR-γ) is a ligand-activated nuclear receptor that plays an essential role in kidney physiology and disease. The synthetic agonists of PPAR-γ shows a therapeutic effect in various kidney conditions; however, the associated side effect restricts their use. Therefore, there is an increasing interest in exploring natural products with PPARγ-activating potential, which can be a promising solution to developing effective and safe treatment of kidney diseases. In this review, we have discussed the role of PPAR-γ in the pathophysiology of kidney disease and the potential of natural PPAR-γ agonists in treating various kidney diseases, including acute kidney injury, diabetic kidney disease, obesity-induced nephropathy, hypertension nephropathy and IgA nephropathy. PPAR-γ is a potential target for the natural PPAR-γ agonists against kidney disease; however, more studies are required in this direction.
肾脏疾病是全球范围内导致巨大健康和经济负担的主要非传染性疾病之一。糖尿病、高血压、肥胖和心血管疾病是肾脏疾病的主要危险因素，其次是感染、毒性和自身免疫性病因。过氧化物酶体增殖物激活受体γ（PPAR-γ）是一种配体激活的核受体，在肾脏生理和疾病中起重要作用。PPAR-γ的合成激动剂在各种肾脏疾病中显示出治疗效果；然而，相关的副作用限制了它们的使用。因此，人们对探索具有PPARγ激活潜力的天然产物越来越感兴趣，这可能是开发有效且安全的肾脏疾病治疗方法的一个有前景的解决方案。在这篇综述中，我们讨论了PPAR-γ在肾脏疾病病理生理学中的作用以及天然PPAR-γ激动剂在治疗各种肾脏疾病中的潜力，包括急性肾损伤、糖尿病肾病、肥胖性肾病、高血压肾病和IgA肾病。PPAR-γ是天然PPAR-γ激动剂对抗肾脏疾病的一个潜在靶点；然而，在这个方向上还需要更多的研究。
