Ahmed Faizan, Spindel Jeffrey F, Belur Agastya, Ghafghazi Shahab
University of Louisville School of Medicine, Department of Internal Medicine.
University of Louisville School of Medicine, Division of Cardiovascular Medicine.
Glob Cardiol Sci Pract. 2022 Jun 30;2022(1-2):e202206. doi: 10.21542/gcsp.2022.6.
Physical, mental, and emotional stressors have been well known to adversely affect cardiac function. A rare complication of such stressors is stress cardiomyopathy, otherwise known as takotsubo cardiomyopathy. First identified in Japan in the 1990s, takotsubo cardiomyopathy classically presents with systolic dysfunction and apical ballooning. In this report, we present the case of a patient with a medical history of alcohol abuse who presented to the emergency department after being found unresponsive by her family. Transthoracic echocardiography revealed takotsubo cardiomyopathy, which was likely secondary to alcohol withdrawal. Alcohol withdrawal causes an imbalance between various neurotransmitters such as GABA and glutamate. This imbalance caused autonomic overactivity, which manifested as stress cardiomyopathy.
众所周知，身体、精神和情绪上的压力源会对心脏功能产生不利影响。此类压力源的一种罕见并发症是应激性心肌病，又称Takotsubo心肌病。Takotsubo心肌病于20世纪90年代在日本首次被发现，典型表现为收缩功能障碍和心尖部气球样变。在本报告中，我们介绍了一名有酒精滥用病史的患者的病例，该患者被家人发现无反应后被送往急诊科。经胸超声心动图显示为Takotsubo心肌病，可能继发于酒精戒断。酒精戒断会导致γ-氨基丁酸（GABA）和谷氨酸等各种神经递质之间的失衡。这种失衡导致自主神经活动过度，表现为应激性心肌病。
