Alanazi Mana A, El-Hiti Gamal A, Alturki Osamah A, Alanazi Muteb, Fagehi Raied, Masmali Ali M
Cornea Research Chair, Department of Optometry, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
J Ophthalmol. 2022 Oct 27;2022:9970388. doi: 10.1155/2022/9970388. eCollection 2022.
Smoking has a negative effect on health and ocular tear film. The purpose of the current study is to investigate the correlation between the TearLab and I-Pen osmolarity scores in smokers and compare them with those of non-smoking healthy males.
Thirty male smokers (25.3 ± 2.2 years) participated in the study. An age-matched (22.9 ± 2.0 years) control group of non-smoking healthy males ( = 30) was also recruited for comparison purposes. The ocular surface disease index (OSDI) was completed first, followed by the TearLab and I-Pen osmolarity measurements.
The median TearLab osmolarity score was lower ( < 0.001) than that obtained using the I-Pen in both the study and the control groups. The OSDI scores and osmolality measurements were higher ( < 0.001) in smokers than in the control subjects. In the smoker group, there were moderate correlations between the OSDI scores and the measurements obtained using the TearLab (Spearman's correlation coefficient, = 0.463; = 0.010) and I-Pen ( = 0.449; = 0.013) systems. In addition, there was a strong correlation between the osmolarity scores obtained from the TearLab and I-Pen systems in smokers ( = 0.911; < 0.001).
The I-Pen scores in smokers were significantly higher than those obtained using TearLab. The TearLab scores showed small variations compared with those obtained using I-Pen. A strong correlation was found between the TearLab and I-Pen scores in smokers. The osmolarity TearLab and I-Pen scores were significantly higher in smokers compared with normal eye subjects.
吸烟对健康和眼表泪膜有负面影响。本研究旨在调查吸烟者泪液实验室（TearLab）和I-Pen渗透压评分之间的相关性，并将其与非吸烟健康男性的评分进行比较。
30名男性吸烟者（25.3±2.2岁）参与了本研究。还招募了一个年龄匹配（22.9±2.0岁）的非吸烟健康男性对照组（n=30）用于比较。首先完成眼表疾病指数（OSDI），随后进行泪液实验室和I-Pen渗透压测量。
在研究组和对照组中，泪液实验室渗透压评分中位数均低于使用I-Pen获得的评分（P<0.001）。吸烟者的OSDI评分和渗透压测量值高于对照组（P<0.001）。在吸烟组中，OSDI评分与使用泪液实验室（Spearman相关系数，r=0.463；P=0.010）和I-Pen（r=0.449；P=0.013）系统获得的测量值之间存在中度相关性。此外，吸烟者泪液实验室和I-Pen系统获得的渗透压评分之间存在强相关性（r=0.911；P<0.001）。
吸烟者的I-Pen评分显著高于使用泪液实验室获得的评分。与使用I-Pen获得的评分相比，泪液实验室评分变化较小。吸烟者泪液实验室和I-Pen评分之间存在强相关性。与正常眼受试者相比，吸烟者的泪液实验室和I-Pen渗透压评分显著更高。
