Alanazi Mana A, El-Hiti Gamal A, Al-Madani Alaa, Fagehi Raied
Department of Optometry, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
Cornea Research Chair, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
J Ophthalmol. 2021 Jan 23;2021:9524143. doi: 10.1155/2021/9524143. eCollection 2021.
To evaluate the dry eye symptoms and ocular tear film in young female subjects with refractive errors (RE) using the ocular surface disease index (OSDI), phenol red thread (PRT) and tear ferning (TF) tests. . A group of 50 young female subjects (mean ± standard division = 20.3 ± 1.1 years) with RE (-0.25 to -6.00D) completed the study. An age-matched control group consisting of 50 healthy normal eye female subjects (22.2 ± 1.5 years) was recruited for comparison. The OSDI was completed first, followed by PRT and TF tests. . Median OSDI and TF scores were significantly higher (Mann-Whitney test; < 0.001) among the study group subjects [median (interquartile range (IQR)) = 13.5 (15.3) and 1.6 (1.3), respectively] compared to the control group [6.0 (4.0) and 0.9 (0.8), respectively], whereas the median PRT score was significantly lower (Mann-Whitney test; =0.003) in the study group [(27.5 (6.3) mm] compared to the control group [29.5 (5.0) mm]. For subjects within the mild RE group ( = 30), significant differences (Mann-Whitney test, < 0.001 to 0.005) were found between the median OSDI, PRT, and TF scores and those recorded within the control group. For the subjects with moderate RE ( = 20), significant differences (Mann-Whitney test, < 0.001 to 0.002) were found between the median OSDI and TF scores, and those recorded within the control group. . The presence of RE in young females has a negative effect on tear film in terms of dry eye symptoms, tear volume, and TF grades. Dry eye symptoms experienced by subjects with RE and the TF grades were significantly higher compared with the control group. In addition, the tear volume was significantly lower in the study group. Clearly, RE has a risk factor for dry eye.
使用眼表疾病指数（OSDI）、酚红棉线（PRT）和泪液蕨样变（TF）试验评估患有屈光不正（RE）的年轻女性受试者的干眼症状和眼表泪膜。一组50名患有RE（-0.25至-6.00D）的年轻女性受试者（平均±标准差=20.3±1.1岁）完成了该研究。招募了由50名健康正常眼女性受试者（22.2±1.5岁）组成的年龄匹配对照组进行比较。首先完成OSDI，然后进行PRT和TF试验。与对照组[分别为6.0（4.0）和0.9（0.8）]相比，研究组受试者的OSDI和TF评分中位数显著更高（曼-惠特尼检验；<0.001）[中位数（四分位间距（IQR））分别为13.5（15.3）和1.6（1.3）]，而研究组的PRT评分中位数[（27.5（6.3）mm]显著低于对照组[29.5（5.0）mm]（曼-惠特尼检验；=0.003）。对于轻度RE组（n=30）的受试者，发现其OSDI、PRT和TF评分中位数与对照组记录的评分之间存在显著差异（曼-惠特尼检验，<0.001至0.005）。对于中度RE的受试者（n=20），发现其OSDI和TF评分中位数与对照组记录的评分之间存在显著差异（曼-惠特尼检验，<0.001至=0.002）。年轻女性中RE的存在在干眼症状、泪液量和TF分级方面对泪膜有负面影响。与对照组相比，患有RE的受试者经历的干眼症状和TF分级显著更高。此外，研究组的泪液量显著更低。显然，RE是干眼的一个危险因素。
