神经免疫相互作用和病理过程中的血脑屏障
The Blood-Brain Barrier in Neuroimmune Interactions and Pathological Processes.
作者信息
Dyatlova A S, Novikova N S, Yushkov B G, Korneva E A, Chereshnev V A
机构信息
Institute of Experimental Medicine (IEM), St. Petersburg, Russia.
Institute of Immunology and Physiology (IIP), Ural Branch, Russian Academy of Sciences, Yekaterinburg, Russia.
出版信息
Her Russ Acad Sci. 2022;92(5):590-599. doi: 10.1134/S1019331622050100. Epub 2022 Nov 2.
The blood-brain barrier (BBB) is a kind of filter, highly selective in relation to various types of substances. The BBB supports the immune status of the brain and is an important regulator of neuroimmune interactions. Some of the molecular and cellular features of the BBB, as well as the five main pathways of neuroimmune communication mediated by the BBB, are analyzed in this article. The functions of the BBB in neuroimmune interactions in various diseases are discussed: multiple sclerosis and Alzheimer's and Parkinson's diseases. The latest data on BBB dysfunction in COVID-19 coronavirus infection caused by the SARS-CoV-2 virus are considered.
血脑屏障（BBB）是一种过滤器，对各种类型的物质具有高度选择性。血脑屏障维持着大脑的免疫状态，是神经免疫相互作用的重要调节因子。本文分析了血脑屏障的一些分子和细胞特征，以及由血脑屏障介导的神经免疫通信的五个主要途径。还讨论了血脑屏障在多种疾病（如多发性硬化症、阿尔茨海默病和帕金森病）的神经免疫相互作用中的功能。同时考虑了由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒引起的2019冠状病毒病（COVID-19）感染中血脑屏障功能障碍的最新数据。
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