慢性自发性荨麻疹瘙痒中丘脑 - 小脑 - 搔抓神经回路的功能连接受损
Functional connectivity impairment of thalamus-cerebellum-scratching neural circuits in pruritus of chronic spontaneous urticaria.
作者信息
Zhang Leixiao, Zou Zihao, Yu Siyi, Xiao Xianjun, Shi Yunzhou, Cao Wei, Liu Ying, Zheng Hui, Zheng Qianhua, Zhou Siyuan, Yao Junpeng, Deng Yanli, Yang Qian, Chen Sijue, Hao Pingsheng, Li Ning, Li Ying
机构信息
Department of Integrated Traditional and Western Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
出版信息
Front Neurosci. 2022 Oct 20;16:1026200. doi: 10.3389/fnins.2022.1026200. eCollection 2022.
UNLABELLED
Pruritus of chronic spontaneous urticaria (CSU) is one of the most common and irritating sensations that severely affects the quality of life. However, the changes in the functional connectivity (FC) between thalamic subregions and other brain regions have not been fully elucidated. This study aimed to explore the potential changes in brain neural circuits by focusing on various subregions of the thalamus in patients with CSU pruritus to contribute to the understanding of chronic pruritus from the perspective of central mechanisms. A total of 56 patients with CSU and 30 healthy controls (HCs) completed the data analysis. Urticaria Activity Score 7 (UAS7), pruritus visual analog score (VAS-P), Dermatological Life Quality Index (DLQI), and immunoglobulin E (IgE) values were collected to assess clinical symptoms. Seed-based resting-state functional connectivity (rs-FC) analysis was used to assess relevant changes in the neural circuits of the brain. Compared to HCs, seeds within the caudal temporal thalamus (cTtha) on the right side of patients with CSU showed increased rs-FC with the cerebellum anterior lobe (CAL). Seeds within the lateral prefrontal thalamus (lPFtha) on the right side showed increased rs-FC with both CAL and pons, while those within the medial prefrontal thalamus (mPFtha) on the right side showed increased rs-FC with both CAL and the dorsal lateral prefrontal cortex (dlPFC) on the right side. Seeds within the posterior parietal thalamus (PPtha) on the right side showed increased rs-FC with the cerebellum posterior lobe (CPL) on the left side. The UAS7 values and IgE levels were positively correlated with the rs-FC of the right dlPFC. Our results suggest that patients with CSU may exhibit stronger rs-FC alterations between certain thalamic subregions and other brain regions. These changes affect areas of the brain involved in sensorimotor and scratching.
TRIAL REGISTRATION NUMBER
[http://www.chictr.org.cn], identifier [ChiCTR1900022994].
未标注
慢性自发性荨麻疹（CSU）的瘙痒是最常见且令人不适的症状之一，严重影响生活质量。然而，丘脑亚区域与其他脑区之间的功能连接（FC）变化尚未完全阐明。本研究旨在通过关注CSU瘙痒患者丘脑的各个亚区域，探索脑神经网络的潜在变化，以从中枢机制角度促进对慢性瘙痒的理解。共有56例CSU患者和30名健康对照（HCs）完成了数据分析。收集荨麻疹活动评分7（UAS7）、瘙痒视觉模拟评分（VAS-P）、皮肤病生活质量指数（DLQI）和免疫球蛋白E（IgE）值以评估临床症状。基于种子点的静息态功能连接（rs-FC）分析用于评估脑神经网络的相关变化。与HCs相比，CSU患者右侧尾侧颞叶丘脑（cTtha）内的种子点与小脑前叶（CAL）的rs-FC增加。右侧外侧前额叶丘脑（lPFtha）内的种子点与CAL和脑桥的rs-FC均增加，而右侧内侧前额叶丘脑（mPFtha）内的种子点与CAL和右侧背外侧前额叶皮质（dlPFC）的rs-FC均增加。右侧顶叶后丘脑（PPtha）内的种子点与左侧小脑后叶（CPL）的rs-FC增加。UAS7值和IgE水平与右侧dlPFC的rs-FC呈正相关。我们的结果表明，CSU患者在某些丘脑亚区域与其他脑区之间可能表现出更强的rs-FC改变。这些变化影响参与感觉运动和搔抓的脑区。
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