College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310032, China.
J Ethnopharmacol. 2023 Feb 10;302(Pt A):115870. doi: 10.1016/j.jep.2022.115870. Epub 2022 Oct 29.
Rubus idaeus Linnaeus (RI) is a Chinese herbal medicine that has been widely used in China for a long time to reinforce the kidney, nourish the liver, improve vision, and arrest polyuria.
This work aims to evaluate the recent progress of the chemical composition, pharmacological activity, pharmacokinetics, metabolism, and quality control and of Rubus idaeus, which focuses on the insufficiency of existing research and will shed light on future studies of Rubus idaeus.
Literatures about "Rubus idaeus","Red raspberry" and "Fupenzi"are retrieved by browsing the database, such as Web of Science (http://www.webofknowledge.com/wos), Pubmed (https://pubmed.ncbi.nlm.nih.gov/), CNKI (http://www.cnki.net/), and Wanfang Data (http://www.wanfangdata.com.cn). In addition, related textbooks and digital documents are interrogated to provide a holistic and critical review of the topic. The period of the literature covered from 1981 to 2022.
Approximately 194 compounds have been isolated from Rubus idaeus, which is rich in phenols, terpenoids, alkaloids, steroids, and fatty acids. Numerous investigations have demonstrated that Rubus idaeus exhibits many pharmacological activities, including hypoglycemic and hypolipidemic, anti-Alzheimer effect, anti-osteoporosis, hepatoprotective, anti-cancer, neuroprotective, anti-bacteria and skin care, etc. However, it is worth noting that most of the research is not associated with the conventional effect, such as reducing urination and treating opacity of the cornea.
The effectiveness of Rubus idaeus has been proved by its long-term clinical application. The research on the pharmacological activity of Rubus idaeus has flourished. In many pharmacological experiments, only the high-dose group can achieve the corresponding efficacy, so the efficacy of Rubus idaeus needs to be further interrogated. Meanwhile, the relationship between pharmacological activity and specific compounds of Rubus idaeus has not been clarified yet. Last but not least, studies involving toxicology and pharmacokinetics are very limited. Knowledge of bioavailability and toxicological behavior of Rubus idaeus can help understand the herb's pharmacodynamic and safety profile.
悬钩子属植物（Rubus idaeus Linnaeus，RI）是一种在中国被广泛应用于补肾、养肝、明目和止尿多的中草药。
本研究旨在评估悬钩子属植物化学成分、药理活性、药代动力学、代谢和质量控制的最新进展，重点关注现有研究的不足，并为悬钩子属植物的未来研究提供启示。
通过浏览数据库（如 Web of Science（http://www.webofknowledge.com/wos）、Pubmed（https://pubmed.ncbi.nlm.nih.gov/）、中国知网（http://www.cnki.net/）和万方数据（http://www.wanfangdata.com.cn）等）检索关于“悬钩子属植物”、“覆盆子”和“覆盆”的文献，并查阅相关教科书和数字文献，对该主题进行全面而批判性的综述。文献涵盖的时间范围为 1981 年至 2022 年。
从悬钩子属植物中已分离出约 194 种化合物，其中富含酚类、萜类、生物碱、甾体和脂肪酸。大量研究表明，悬钩子属植物具有多种药理活性，包括降血糖和降血脂、抗阿尔茨海默病、抗骨质疏松、保肝、抗癌、神经保护、抗菌和护肤等。然而，值得注意的是，大多数研究与减少排尿和治疗角膜混浊等常规功效无关。
悬钩子属植物的有效性已通过其长期的临床应用得到证明。对悬钩子属植物药理活性的研究蓬勃发展。在许多药理实验中，只有高剂量组才能达到相应的疗效，因此悬钩子属植物的疗效需要进一步研究。同时，悬钩子属植物的药理活性与特定化合物之间的关系尚未阐明。最后但同样重要的是，涉及毒理学和药代动力学的研究非常有限。对悬钩子属植物生物利用度和毒理学行为的了解有助于理解其药效学和安全性特征。
