Case Western Reserve University, Cleveland, Ohio 44106, USA.
Louisiana State University, Baton Rouge, Louisiana 70803, USA.
Genes Dev. 2022 Jul 1;36(13-14):765-769. doi: 10.1101/gad.349748.122.
The nucleolus is best known for housing the highly ordered assembly line that produces ribosomal subunits. The >100 ribosome assembly factors in the nucleolus are thought to cycle between two states: an operative state (when integrated into subunit assembly intermediates) and a latent state (upon release from intermediates). Although it has become commonplace to refer to the nucleolus as "being a multilayered condensate," and this may be accurate for latent factors, there is little reason to think that such assertions pertain to the operative state of assembly factors.
核仁最广为人知的功能是为核糖体亚基的高度有序装配流水线提供场所。核仁中 >100 种核糖体组装因子被认为在两种状态之间循环：有活性的状态（整合到亚基组装中间物时）和潜伏的状态（从中间物释放时）。尽管将核仁称为“多层凝聚物”已经很常见，但对于潜伏因子来说，这可能是准确的，但几乎没有理由认为这些说法适用于装配因子的有活性状态。
