聚吡咯/CuO 纳米复合材料修饰的纳米多孔金膜传感器用于吡罗昔康和曲马多的电化学测定。
A nanoporous gold film sensor modified with polypyrrole/CuO nanocomposite for electrochemical determination of piroxicam and tramadole.
机构信息
Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R, Iran.
Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R, Iran; Institute of Nano Science and Nano Technology, University of Kashan, Kashan, P.O. Box 87317-51167, I.R, Iran.
出版信息
Environ Res. 2023 Jan 1;216(Pt 3):114633. doi: 10.1016/j.envres.2022.114633. Epub 2022 Nov 4.
In this paper, an electrochemical sensor was developed to determine piroxicam (PX) and tramadole (Tr) based on their enhanced electrochemical responses at the surface of the polypyrrole/CuO nanocomposite-modified nanoporous gold film (NPGF) electrode. The experimental results showed that PX provide an oxidation peak at 0.65 V in pH = 8.0. The DPV results were linearly affiliated on PX concentration within the two closed windows (C1 = 0.05-30.0 μM, correlation coefficient of 0.9905, and C2 = 50.0-300.0 μM, correlation coefficient of 0.9927). From voltammetric curves, the detection limit (LOD = 3S/m) for PX at a surface of PPY-CuO-NPGF electrode was appeared to be 0.01 μM. Furthermore, the ability of PPY-CuO-NPGF electrode for simultaneous measurement of PX and Tr was investigated. The suggested sensor shows a long-time stability, good repeatability, and rapid response in the mixture media of PX and Tr.
本文基于聚吡咯/氧化铜纳米复合材料修饰的纳米多孔金膜（NPGF）电极表面吡罗昔康（PX）和曲马多（Tr）电化学响应的增强，开发了一种电化学传感器来测定 PX 和 Tr。实验结果表明，在 pH = 8.0 时，PX 在 0.65 V 处提供一个氧化峰。DPV 结果表明，在两个封闭窗口内（C1 = 0.05-30.0 μM，相关系数为 0.9905，和 C2 = 50.0-300.0 μM，相关系数为 0.9927），PX 的浓度与 DPV 结果呈线性关系。从伏安曲线可以看出，在 PPY-CuO-NPGF 电极表面上，PX 的检测限（LOD = 3S/m）为 0.01 μM。此外，还研究了 PPY-CuO-NPGF 电极对 PX 和 Tr 同时测定的能力。该传感器在 PX 和 Tr 的混合介质中表现出长时间稳定性、良好的重现性和快速响应。
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