Xu Ming-Min, Gu Li-Hong, Lv Wan-Yue, Duan Sheng-Chang, Li Lian-Wei, Du Yuan, Lu Li-Zhi, Zeng Tao, Hou Zhuo-Cheng, Ma Zhanshan Sam, Chen Wei, Adeola Adeniyi C, Han Jian-Lin, Xu Tie-Shan, Dong Yang, Zhang Ya-Ping, Peng Min-Sheng
State Key Laboratory of Genetic Resources and Evolution & Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China.
Institute of Animal Science & Veterinary Medicine, Hainan Academy of Agricultural Sciences, Haikou 571100, China.
Genomics. 2022 Nov;114(6):110518. doi: 10.1016/j.ygeno.2022.110518. Epub 2022 Nov 5.
The Muscovy duck (Cairina moschata) is an economically important poultry species, which is susceptible to fatty liver. Thus, the Muscovy duck may serve as an excellent candidate animal model of non-alcoholic fatty liver disease. However, the mechanisms underlying fatty liver development in this species are poorly understood. In this study, we report a chromosome-level genome assembly of the Muscovy duck, with a contig N50 of 11.8 Mb and scaffold N50 of 83.16 Mb. The susceptibility of Muscovy duck to fatty liver was mainly attributed to weak lipid catabolism capabilities (fatty acid β-oxidation and lipolysis). Furthermore, conserved noncoding elements (CNEs) showing accelerated evolution contributed to fatty liver formation by down-regulating the expression of genes involved in hepatic lipid catabolism. We propose that the susceptibility of Muscovy duck to fatty liver is an evolutionary by-product. In conclusion, this study revealed the potential mechanisms underlying the susceptibility of Muscovy duck to fatty liver.
番鸭（Cairina moschata）是一种具有重要经济价值的家禽品种，易患脂肪肝。因此，番鸭可能是一种优秀的非酒精性脂肪肝病候选动物模型。然而，该物种脂肪肝发生的潜在机制尚不清楚。在本研究中，我们报道了番鸭的染色体水平基因组组装，其重叠群N50为11.8 Mb，支架N50为83.16 Mb。番鸭对脂肪肝的易感性主要归因于脂质分解代谢能力（脂肪酸β-氧化和脂解）较弱。此外，显示加速进化的保守非编码元件（CNEs）通过下调参与肝脏脂质分解代谢的基因表达，促进了脂肪肝的形成。我们认为番鸭对脂肪肝的易感性是一种进化副产物。总之，本研究揭示了番鸭对脂肪肝易感性的潜在机制。
