School of Biomedical Sciences, Hunan University, Changsha, China.
Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois.
Transl Res. 2023 May;255:159-170. doi: 10.1016/j.trsl.2022.11.004. Epub 2022 Nov 5.
Clonal hematopoiesis (CH) occurs in hematopoietic stem cells with increased risks of progressing to hematologic malignancies. CH mutations are predominantly found in aged populations and correlate with an increased incidence of cardiovascular and other diseases. Increased lines of evidence demonstrate that CH mutations are closely related to the inflammatory bone marrow microenvironment. In this review, we summarize the recent advances in this topic starting from the discovery of CH and its mutations. We focus on the most commonly mutated and well-studied genes in CH and their contributions to the innate immune responses and inflammatory signaling, especially in the hematopoietic cells of bone marrow. We also aimed to discuss the interrelationship between inflammatory bone marrow microenvironment and CH mutations. Finally, we provide our perspectives on the challenges in the field and possible future directions to help understand the pathophysiology of CH.
克隆性造血 (CH) 发生在造血干细胞中，其进展为血液系统恶性肿瘤的风险增加。CH 突变主要存在于老年人群中，与心血管疾病和其他疾病的发病率增加相关。越来越多的证据表明，CH 突变与炎症性骨髓微环境密切相关。在这篇综述中，我们从 CH 的发现及其突变开始，总结了这一主题的最新进展。我们重点介绍了 CH 中最常见和研究最多的突变基因及其对固有免疫反应和炎症信号的贡献，特别是在骨髓造血细胞中。我们还旨在讨论炎症性骨髓微环境与 CH 突变之间的相互关系。最后，我们对该领域的挑战和可能的未来方向提出了看法，以帮助理解 CH 的病理生理学。
