School of Life Science, Liaocheng University, Liaocheng, Shandong, 252000, China.
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan, 621010, China.
Biol Trace Elem Res. 2023 Aug;201(8):3804-3811. doi: 10.1007/s12011-022-03470-6. Epub 2022 Nov 9.
The purpose of this study is to investigate the effects of molybdenosis on antioxidant capacity in endangered Przewalski's gazelles (Procapra przewalskii) in the animal rescue center in the Qinghai Lake National Nature Reserve in Northwestern China. Ten P. przewalskii in molybdenosis were selected and treated orally with copper sulfate (CuSO) at a dose of 20 g/animal/5 days for 20 days. Ten healthy P. przewalskii were also selected and allocated to healthy pastures for 20 days. Samples of soil, forage, and animal tissue were collected. The values of mineral and hematological parameters were measured. Results showed levels of molybdenum (Mo) in soil and forage were significantly higher than those in healthy ranches (P < 0.01). The Mo content of blood and hair in gazelles from the rescue center was also significantly higher than those in the healthy ranches animals (P < 0.01). The copper (Cu) contents in blood and hair from the rescue center were significantly lower than those from the healthy pasture (P < 0.01). Hemoglobin (Hb) and red cell volume (PCV) in the gazelles from the animal rescue center were significantly lower than those from animals in healthy ranches (P < 0.01). Aspartate aminotransferase (AST), lactate dehydrogenase (LDH), phosphocreatine kinase (CPK), and alkaline phosphatase (ALP) were significantly higher than those from gazelles in healthy ranches (P < 0.01). The antioxidant capacity in gazelles from the animal rescue center was significantly lower than that of gazelles in healthy ranches. Supplementing CuSO significantly decreased the Mo content of blood and cured molybdenosis in gazelles. In summary, the Mo content of soil and forage was very excessive for gazelles in the animal rescue center. The antioxidant capacity of P. przewalskii has been seriously affected by molybdenosis.
本研究旨在探讨中国西北青海湖国家级自然保护区动物救助中心的地方性钼中毒对濒危普氏原羚（Procapra przewalskii）抗氧化能力的影响。选择 10 只患有钼中毒的普氏原羚，口服硫酸铜（CuSO），剂量为 20g/动物/5 天，共 20 天。同时选择 10 只健康的普氏原羚分配到健康的牧场中，持续 20 天。采集土壤、饲料和动物组织样本。测量矿物质和血液学参数值。结果表明，救助中心土壤和饲料中的钼含量明显高于健康牧场（P < 0.01）。救助中心普氏原羚的血液和毛发中的钼含量也明显高于健康牧场的动物（P < 0.01）。救助中心血液和毛发中的铜含量明显低于健康牧场的动物（P < 0.01）。救助中心普氏原羚的血红蛋白（Hb）和红细胞压积（PCV）明显低于健康牧场的动物（P < 0.01）。天冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、磷酸肌酸激酶（CPK）和碱性磷酸酶（ALP）明显高于健康牧场的动物（P < 0.01）。救助中心普氏原羚的抗氧化能力明显低于健康牧场的普氏原羚。补充 CuSO 可显著降低血液中的钼含量并治愈普氏原羚的钼中毒。综上所述，救助中心普氏原羚的土壤和饲料中的钼含量非常高。普氏原羚的抗氧化能力已受到钼中毒的严重影响。
