Ren X T, Guo T, Yang F, Wu W Y, Dou H L, Li X M
Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Beijing 100191, China.
Zhonghua Yan Ke Za Zhi. 2022 Nov 11;58(11):925-928. doi: 10.3760/cma.j.cn112142-20220215-00055.
A 53-year-old female patient complained of 1 week of bilateral visual blurring. She was previously diagnosed with metastatic melanoma of the inguinal lymph nodes and treated with the oral targeted drug vemurafenib. She exhibited aqueous flare in the left eye, and her fundus examination revealed optic disc swelling in the left eye and bilateral serious detachment of the retinal neuroepithelial layer. Fluorescein angiography showed multiple pinpoint hyperfluorescence leakage spots in the prometaphase and appeared as multilobular dye pooling in the late phase. We diagnosed her as Vogt-Koyanagi-Harada syndrome and gave glucocorticoid treatment for eyes. Oral vemurafenib was also taken intermittently under the guidance of an oncologist. After treatment, her bilateral vision improved, the anterior segment inflammation disappeared, and the retinal neuroepithelial layer reattached, with presence of the "sunset glow" fundus.
一名53岁女性患者主诉双眼视力模糊1周。她之前被诊断为腹股沟淋巴结转移性黑色素瘤，并接受了口服靶向药物维莫非尼治疗。她左眼出现房水闪光，眼底检查发现左眼视盘肿胀，双眼视网膜神经上皮层严重脱离。荧光素血管造影显示，前期有多个针尖状高荧光渗漏点，后期呈多叶状染料池。我们将她诊断为Vogt-小柳原田综合征，并给予眼部糖皮质激素治疗。在肿瘤学家的指导下，还间歇性服用口服维莫非尼。治疗后，她的双眼视力改善，前段炎症消失，视网膜神经上皮层重新附着，眼底出现“晚霞”征。
