Bereda Gudisa
Department of Pharmacy, Negelle Health Science College, Negelle, ETH.
Cureus. 2022 Oct 2;14(10):e29842. doi: 10.7759/cureus.29842. eCollection 2022 Oct.
In many parts of the world, particularly in impoverished nations like Ethiopia, organophosphate compounds operate as suicide agents, are frequently employed as pesticides, and are strong inhibitors of the acetylcholinesterase enzyme. A 21-year-old Ethiopian female, a university student, was admitted to an emergency department on June 22, 2022, with a two-hour history of nausea and elevated secretions of salivation via the mouth. She had no previous history of psychiatric or neurological disorders, but three days before her admission, she quarreled with her boyfriend, became extremely depressed, and decided to commit suicide. She had a two-hour history of nausea and intermittent vomiting and a one-hour history of persistent vomiting, increased salivation secretions through the mouth, chills, progressive sweating, difficulty breathing, and dizziness. Upon admission, her neurological examination in the emergency department revealed a Glasgow Coma Scale score of 9/15. On admission, she was placed on two liters per minute of intranasal oxygen via the nasal cannula. On the same day, she was given atropine 0.15 mg intravenously, and the dose was doubled every 10 minutes until atropinization was achieved, and a bolus dose of 500ml of 0.9% of normal saline was initiated immediately.
在世界许多地区,尤其是在像埃塞俄比亚这样的贫困国家,有机磷化合物被用作自杀工具,经常被用作杀虫剂,并且是乙酰胆碱酯酶的强效抑制剂。一名21岁的埃塞俄比亚女大学生于2022年6月22日被送往急诊科,有两小时的恶心病史,口腔唾液分泌增多。她既往无精神或神经疾病史,但入院前三天,她与男友争吵,极度抑郁,决定自杀。她有两小时的恶心和间歇性呕吐病史,一小时的持续性呕吐病史,口腔唾液分泌增多,发冷,进行性出汗,呼吸困难和头晕。入院时,她在急诊科的神经系统检查显示格拉斯哥昏迷量表评分为9/15。入院时,通过鼻导管给予她每分钟两升的鼻内氧气。同一天,静脉给予她0.15毫克阿托品,每10分钟剂量加倍,直至达到阿托品化,并立即开始推注500毫升0.9%的生理盐水。