Nanji A A, Denardi F G
Med Hypotheses. 1986 Jan;19(1):1-6. doi: 10.1016/0306-9877(86)90131-3.
We have compared the incidence of inflammatory bowel disease (IBD) to the prevalence of lactose malabsorption (LM) in several countries. Our observations indicate that IBD is rare where LM is highly prevalent. The correlation between incidence of Crohn's disease and LM is -0.93, p less than 0.01, the correlation between incidence of ulcerative colitis and LM is -0.89, p less than 0.01. We, therefore, propose that LM results in the formation of volatile fatty acids which may inhibit multiplication of potentially pathogenic organisms.
我们比较了几个国家炎症性肠病（IBD）的发病率与乳糖吸收不良（LM）的患病率。我们的观察结果表明，在LM高度流行的地区，IBD很少见。克罗恩病发病率与LM之间的相关性为-0.93，p<0.01，溃疡性结肠炎发病率与LM之间的相关性为-0.89，p<0.01。因此，我们提出，LM会导致挥发性脂肪酸的形成，而挥发性脂肪酸可能会抑制潜在致病生物的繁殖。
