Tavoloni Tamara, Stramenga Arianna, Stecconi Tommaso, Gavaudan Stefano, Moscati Livia, Sagratini Gianni, Siracusa Melania, Ciriaci Martina, Dubbini Alessandra, Piersanti Arianna
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Via Cupa di Posatora 3, 60131 Ancona, Italy.
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Via G. Salvemini 1, 06126 Perugia, Italy; University of Camerino, School of Pharmacy, 62032 Camerino, Italy.
Sci Total Environ. 2023 Feb 1;858(Pt 1):159745. doi: 10.1016/j.scitotenv.2022.159745. Epub 2022 Oct 28.
Twenty-six samples of wild boar liver and muscle from the Central Apennine Mountain (Italy) were analysed for 19 perfluoro-alkyl substances (PFASs), 10 polybrominated diphenylethers (PBDEs) and 3 hexabromocyclododecanes (HBCDs). All samples were analysed by gas chromatography-tandem mass spectrometry for PBDEs and liquid chromatography-tandem mass spectrometry for PFASs and HBCDs, using an in-house developed analytical procedure. The brominated flame retardants (BFR) levels in livers were negligible: ΣPBDEs reached a maximum value of 0.079 μg/kg, whereas HBCDs were not quantified in almost all of the samples analysed. BFR concentrations in muscles were higher, but not significantly therefore, for ΣPBDEs lower bound, a mean value of 0.045 μg/kg (0.005-0.155 μg/kg range) was measured, while α-HBCD was quantified with a maximum of 0.084 μg/kg in 9 of the samples. Only two muscles contained all 3 HBCD isomers at concentrations of approximately 0.200 μg/kg. ΣPFAS in the 26 wild boar livers was in the range 31.9-228 μg/kg, with a mean value of 87.7 μg/kg, reaching levels significantly higher than in muscles, which exhibited a mean concentration of 3.08 μg/kg (0.59-9.12 μg/kg range). Perfluorooctanesulfonic acid (PFOS) was the most prevalent compound in all liver samples, accounting for more than half of the total PFASs contamination, confirming that the liver is the primary target organ for PFOS exposure Perfluorotridecanoic acid (PFTrDA), which accounts for 25-30-% of the total contamination, was the most abundant compound in the muscle, followed by PFOS. The estimated daily intake (EDIs) of BFRs remained below the estimated chronic human daily dietary intake (D) defined from European Food Safety Authority (EFSA). Furthermore, the exposure to PFASs in muscle was 7.7 times lower than the EFSA's tolerable daily intake (TDI). In contrast, exposure due to liver consumption was significant: the EDI exceeded the EFSA's 2020 TDI by approximately 7 times.
对来自意大利亚平宁山脉中部的26份野猪肝脏和肌肉样本进行了分析，检测其中19种全氟烷基物质（PFASs）、10种多溴二苯醚（PBDEs）和3种六溴环十二烷（HBCDs）的含量。所有样本均采用内部开发的分析程序，通过气相色谱 - 串联质谱法分析PBDEs，液相色谱 - 串联质谱法分析PFASs和HBCDs。肝脏中溴化阻燃剂（BFR）的含量可忽略不计：ΣPBDEs的最大值为0.079μg/kg，而在几乎所有分析样本中均未检测到HBCDs。肌肉中的BFR浓度较高，但差异不显著，因此，对于ΣPBDEs下限，测量的平均值为0.045μg/kg（范围为0.005 - 0.155μg/kg），而α - HBCD在9个样本中的最高定量值为0.084μg/kg。只有两块肌肉含有所有3种HBCD异构体，浓度约为0.200μg/kg。26份野猪肝脏中的ΣPFAS含量在31.9 - 228μg/kg范围内，平均值为87.7μg/kg，显著高于肌肉中的含量，肌肉中的平均浓度为3.08μg/kg（范围为0.59 - 9.12μg/kg）。全氟辛烷磺酸（PFOS）是所有肝脏样本中最普遍的化合物，占总PFASs污染的一半以上，证实肝脏是PFOS暴露的主要靶器官。全氟十三烷酸（PFTrDA）占总污染的25 - 30%，是肌肉中含量最丰富的化合物，其次是PFOS。BFRs的估计每日摄入量（EDIs）仍低于欧洲食品安全局（EFSA）定义的估计慢性人类每日膳食摄入量（D）。此外，肌肉中PFASs的暴露量比EFSA的每日可耐受摄入量（TDI）低7.7倍。相比之下，食用肝脏导致的暴露量显著：EDI超过EFSA 2020年的TDI约7倍。
