1Fox Chase Cancer Center.
2Roswell Park Comprehensive Cancer Center.
J Natl Compr Canc Netw. 2022 Nov;20(11):1204-1214. doi: 10.6004/jnccn.2022.0058.
Gastrointestinal stromal tumors (GIST) are the most common type of soft tissue sarcoma that occur throughout the gastrointestinal tract. Most of these tumors are caused by oncogenic activating mutations in the KIT or PDGFRA genes. The NCCN Guidelines for GIST provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with these tumors. These NCCN Guidelines Insights summarize the panel discussion behind recent important updates to the guidelines, including revised systemic therapy options for unresectable, progressive, or metastatic GIST based on mutational status, and updated recommendations for the management of GIST that develop resistance to specific tyrosine kinase inhibitors.
胃肠道间质瘤（GIST）是胃肠道最常见的软组织肉瘤。这些肿瘤大多是由于 KIT 或 PDGFRA 基因的致癌激活突变引起的。NCCN GIST 指南为这些肿瘤患者的诊断、评估、治疗和随访提供了建议。这些 NCCN 指南见解总结了近期指南重要更新背后的小组讨论，包括根据突变状态修订不可切除、进展或转移性 GIST 的系统治疗选择，以及更新了对特定酪氨酸激酶抑制剂耐药的 GIST 管理建议。
