Urologie 24, Nuremberg, Germany.
Department of Urology and Pediatric Urology, Friedrich-Alexander University, Erlangen, Germany.
Br J Nutr. 2023 Aug 14;130(3):495-502. doi: 10.1017/S0007114522003452. Epub 2022 Nov 10.
Androgen deprivation therapy (ADT) in men with prostate cancer (PCa) is associated with significant side effects. With the transition of PCa from a foudroyant course to a chronic disease, managing these side effects has become increasingly important. There is growing evidence that nutritional changes and physical activity are beneficial in these patients. Here we examine the impact of written patient information on the physical activity and dietary habits of PCa patients receiving ADT and behaviour changes between baseline and 1 year, in the open-label, non-interventional LEAN study. In total, 959 patients with advanced hormone-sensitive PCa requiring ADT with the Leuprorelin Sandoz® implant were included from January 2014 to July 2015 and followed for ≥ 12 months. At the start of the study, urologists received a questionnaire concerning the written information provided to patients regarding their disease, patient advocacy groups, diet and physical activity. Patients received a questionnaire on their dietary habits and physical activity at the start and end of the study. Urologists from 147 study centres and 540 patients responded to the questionnaires. While 69 % of these patients received disease-specific information, only 30 % and 17 % received information regarding nutrition and physical activity, respectively. The majority of urologists estimate that their patients rarely or never follow guidance on nutrition or physical activity, yet > 90 % of patients indicate they would make use of this information, if provided. Few patients showed behavioural changes between baseline and 1 year without evident differences between patients that received information and those that did not.
雄激素剥夺疗法（ADT）在前列腺癌（PCa）男性患者中的应用与显著的副作用相关。随着 PCa 从暴发性疾病向慢性疾病的转变，管理这些副作用变得越来越重要。越来越多的证据表明，营养改变和身体活动对这些患者有益。在这里，我们在 LEAN 开放性、非干预性研究中检查了书面患者信息对接受 ADT 的 PCa 患者的身体活动和饮食习惯的影响，以及行为改变从基线到 1 年的变化。2014 年 1 月至 2015 年 7 月，共纳入 959 例需要 ADT 的晚期激素敏感型 PCa 患者，接受了 Leuprorelin Sandoz®植入物治疗，并随访了≥12 个月。在研究开始时，泌尿科医生收到了一份关于向患者提供的关于疾病、患者权益团体、饮食和身体活动的书面信息的问卷。患者在研究开始和结束时收到了关于饮食习惯和身体活动的问卷。来自 147 个研究中心的 147 名泌尿科医生和 540 名患者对问卷做出了回应。虽然这些患者中有 69%收到了特定于疾病的信息，但只有 30%和 17%分别收到了关于营养和身体活动的信息。大多数泌尿科医生估计他们的患者很少或从不遵循营养或身体活动方面的指导，但如果提供这些信息，超过 90%的患者表示他们会利用这些信息。在没有明显差异的情况下，很少有患者在基线和 1 年内表现出行为改变，这些患者中接受信息的和未接受信息的患者之间没有差异。
