Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Aliment Pharmacol Ther. 2023 Mar;57(5):475-485. doi: 10.1111/apt.17285. Epub 2022 Nov 9.
Sleep dysregulation has been linked to gastrointestinal dysfunction and inflammation.
To explore the associations between sleep duration, daytime napping and inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC).
Exposure information was obtained from the baseline questionnaire. Sleep duration was coded as continuous and categorical (≤5, 6, 7, 8, ≥9 h/day) variables. Daytime napping was defined as yes (sometimes/usually) and no (never/rarely). Incident IBD cases were defined from primary care and hospital inpatient records. Polygenic risk scores (PRS) for the outcomes were constructed and categorised into low, intermediate and high risk. Hazard ratio (HR) and confidence interval (CI) were estimated using Cox proportional hazard regression.
The analysis included 2604 incident IBD cases (806 CD and 1798 UC) with a median follow-up of 12.0 years. Comparing sleep duration ≤5 with 7 h/day, the HR of IBD, CD and UC was 1.36 (95% CI, 1.17-1.59), 1.53 (95% CI, 1.17-2.00) and 1.29 (95% CI, 1.07-1.56), respectively. Comparing participants with and without daytime napping, the HR of IBD, CD and UC was 1.13 (95% CI, 1.05-1.23), 1.25 (95% CI, 1.08-1.44) and 1.09 (95% CI, 0.90-1.20), respectively. No interaction of sleep duration and daytime napping with PRS was detected. However, the associations appeared stronger in individuals with high rather than low PRS.
This study reveals positive associations between short sleep duration and daytime napping and IBD risk.
睡眠失调与胃肠道功能障碍和炎症有关。
探索睡眠时长、白天小睡与炎症性肠病（IBD）、克罗恩病（CD）和溃疡性结肠炎（UC）之间的关联。
暴露信息来自基线问卷。睡眠时长被编码为连续和分类变量（≤5、6、7、8、≥9 小时/天）。白天小睡定义为偶尔/经常和从不/很少。IBD 病例从初级保健和住院记录中确定。构建了结局的多基因风险评分（PRS）并分为低、中、高风险。使用 Cox 比例风险回归估计风险比（HR）和置信区间（CI）。
该分析包括 2604 例新发 IBD 病例（806 例 CD 和 1798 例 UC），中位随访时间为 12.0 年。与 7 小时/天相比，睡眠时长≤5 小时的 IBD、CD 和 UC 的 HR 分别为 1.36（95%CI，1.17-1.59）、1.53（95%CI，1.17-2.00）和 1.29（95%CI，1.07-1.56）。与白天小睡的参与者相比，无白天小睡的 IBD、CD 和 UC 的 HR 分别为 1.13（95%CI，1.05-1.23）、1.25（95%CI，1.08-1.44）和 1.09（95%CI，0.90-1.20）。未检测到睡眠时长和白天小睡与 PRS 的交互作用。然而，在 PRS 较高而非较低的个体中，关联似乎更强。
本研究揭示了短睡眠时长和白天小睡与 IBD 风险之间的正相关关系。
