Hermens Johannes G H, Lepage Mathieu L, Kloekhorst Arjan, Keller Erik, Bloem Robin, Meijer Maurice, Feringa Ben L
Stratingh Institute for Chemistry, Advanced Research Center Chemical Building Blocks Consortium (ARC CBBC), University of Groningen Nijenborgh 4 9747 AG Groningen The Netherlands
Hanze University of Applied Sciences Zernikeplein 11 9747 AS Groningen The Netherlands.
React Chem Eng. 2022 Sep 28;7(11):2280-2284. doi: 10.1039/d2re00310d. eCollection 2022 Oct 25.
The upscaling of biphasic photochemical reactions is challenging because of the inherent constraints of liquid-gas mixing and light penetration. Using semi-permeable coaxial flow chemistry within a modular photoreactor, the photooxidation of the platform chemical furfural was scaled up to produce routinely 29 gram per day of biobased building block hydroxybutenolide, a precursor to acrylate alternatives.
由于液-气混合和光穿透的固有限制，双相光化学反应的放大具有挑战性。在模块化光反应器中使用半透同轴流化学方法，平台化学品糠醛的光氧化反应得以放大，常规产量达到每天29克生物基结构单元羟基丁烯内酯，这是丙烯酸酯替代品的前体。
