Cardiothoracic Unit, St. Paul's Hospital, Hong Kong, China.
World J Gastroenterol. 2022 Oct 28;28(40):5801-5806. doi: 10.3748/wjg.v28.i40.5801.
The whole world has been continuously afflicted by the coronavirus disease 2019 (COVID-19) pandemic for the past 3 years. Many countries have tried many methods to control this virus infection with varying successes and failures. The gut microbiota is a biosystem spanning the entire length of the digestive tract and playing important roles in health and disease. It is much affected by COVID-19. In return it also substantially impacts infection. In particular, the gut microbiota has established a bidirectional interaction with the COVID-19 vaccines, enhancing or reducing vaccine efficacy by virtue of its varying components. Conversely, COVID-19 vaccines also make a substantial impact on the gut microbiota, re-ducing its overall population and biodiversity. It is hoped that by exploring and harnessing this bidirectional interaction we may break new ground and develop new methods to prevent and treat this formidable virus infection.
过去 3 年，全世界一直在不断受到 2019 冠状病毒病（COVID-19）大流行的折磨。许多国家尝试了多种方法来控制这种病毒感染，成效不一。肠道微生物群是横跨整个消化道的生物系统，在健康和疾病中发挥着重要作用。它受 COVID-19 的影响很大。反过来，它也对感染产生重大影响。特别是，肠道微生物群与 COVID-19 疫苗建立了双向相互作用，其不同成分增强或降低了疫苗的效力。相反，COVID-19 疫苗也对肠道微生物群产生重大影响，降低了其总体种群和生物多样性。人们希望通过探索和利用这种双向相互作用，开辟新天地，开发预防和治疗这种强大病毒感染的新方法。
