Mehta Jason N, Morales Brianna E, Rossmeisl John H, Debinski Waldemar, Rylander Christopher G
Department of Mechanical Engineering, University of Texas at Austin, 204 E. Dean Keeton Street, Stop C2200, Austin, TX 78712-1591.
Department of Biomedical Engineering, University of Texas at Austin, 301 E. Dean Keeton Street, C2100, Austin, TX 78712-2100.
J Med Device. 2022 Dec 1;16(4):041014. doi: 10.1115/1.4055607. Epub 2022 Sep 27.
Convection-enhanced delivery (CED) is a drug delivery technique used to deliver therapeutics directly to the brain and is a continually evolving technique to treat glioblastoma. Early versions of CED have proven to result in inadequate drug volume dispersed (V), increasing the likelihood of tumor recurrence. Fiber optic microneedle devices (FMDs) with the ability to deliver fluid and thermal energy simultaneously have shown an ability to increase V, but FMDs have historically had low light transmission efficiency. In this study, we present a new fabrication method, solid fiber inside capillary (SFIC) FMD, and a modified fusion splicing (FS) method with the goal of increasing light delivery efficiency. The modified FS FMD resulted in an increase in light transmission efficiency between 49% and 173% compared to previous prototypes. However, the FS FMD resulted in significantly lower transmission efficiencies compared to the SFIC FMD (p ≤ 0.04) and FS FMDs perform much worse when light-absorptive materials, like black dye, are placed in the bore. The light absorption of a candidate cytotoxic agent, QUAD-CTX, appear to be similar to water, and light delivery through FS FMDs filled with QUAD-CTX achieves a transmission efficiency of 85.6 ± 5.4%. The fabrication process of the SFIC FMDs results in extremely fragile FMDs. Therefore, the use of a modified FS FMD fabrication process appears to be better suited for balancing the desire to increase light transmission efficiency while retaining a sturdy FMD construction.
对流增强递送（CED）是一种用于将治疗药物直接递送至大脑的给药技术，是一种不断发展的治疗胶质母细胞瘤的技术。早期版本的CED已被证明会导致药物分散体积（V）不足，增加肿瘤复发的可能性。能够同时输送流体和热能的光纤微针装置（FMD）已显示出增加V的能力，但FMD历来光传输效率较低。在本研究中，我们提出了一种新的制造方法，即毛细管内实心光纤（SFIC）FMD，以及一种改进的熔接（FS）方法，目的是提高光传输效率。与之前的原型相比，改进后的FS FMD的光传输效率提高了49%至173%。然而，与SFIC FMD相比，FS FMD的传输效率显著更低（p≤0.04），并且当在孔中放置吸光材料（如黑色染料）时，FS FMD的性能要差得多。候选细胞毒性剂QUAD-CTX的光吸收似乎与水相似，通过填充QUAD-CTX的FS FMD进行光传输可实现85.6±5.4%的传输效率。SFIC FMD的制造过程会导致FMD极其脆弱。因此，使用改进的FS FMD制造工艺似乎更适合在增加光传输效率的同时保持FMD结构坚固之间取得平衡。
