Sturgill Sarah L, Shettigar Vikram, Ziolo Mark T
Frick Center for Heart Failure and Arrhythmia, Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States.
Front Physiol. 2022 Oct 24;13:969314. doi: 10.3389/fphys.2022.969314. eCollection 2022.
For years, ejection fraction has been an essentially ubiquitous measurement for assessing the cardiovascular function of animal models in research labs. Despite technological advances, it remains the top choice among research labs for reporting heart function to this day, and is often overstated in applications. This unfortunately may lead to misinterpretation of data. Clinical approaches have now surpassed research methods, allowing for deeper analysis of the tiers of cardiovascular performance (cardiovascular performance, heart performance, systolic and diastolic function, and contractility). Analysis of each tier is crucial for understanding heart performance, mechanism of action, and disease diagnosis, classification, and progression. This review will elucidate the differences between the tiers of cardiovascular function and discuss the benefits of measuring each tier speckle tracking echocardiography for basic scientists.
多年来，射血分数一直是研究实验室评估动物模型心血管功能时几乎普遍使用的测量方法。尽管技术不断进步，但时至今日它仍是研究实验室报告心脏功能的首选方法，并且在应用中常常被过度强调。不幸的是，这可能导致数据的错误解读。目前临床方法已经超越了研究方法，能够对心血管性能的各个层次（心血管性能、心脏性能、收缩和舒张功能以及收缩性）进行更深入的分析。对每个层次的分析对于理解心脏性能、作用机制以及疾病的诊断、分类和进展至关重要。本综述将阐明心血管功能各层次之间的差异，并讨论为基础科学家测量每个层次的斑点追踪超声心动图的益处。
