Castillo-Delgado Carlos Alfredo, García-Perdomo Herney Andrés, Musquera Mireia, Alcaraz Antonio
Division of Transplant Surgery, Department of General Surgery, Hospital General Plaza de la Salud, Santo Domingo, Dominican Republic.
Division of Urology/Urooncology, Department of Surgery, UROGIV Research Group, Universidad del Valle, Cali, Colombia.
Arab J Urol. 2022 Jun 17;20(4):212-218. doi: 10.1080/2090598X.2022.2090133. eCollection 2022.
To determine graft and patient survival and adverse events in patients who undergo orthotopic kidney transplantation.
We performed a systematic review and meta-analysis. We search in Medline, Embase, and Central from inception to nowadays. We included observational studies with patients who undergo orthotopic kidney transplantation. The primary outcomes were overall patient and graft survival. We pooled the information in a frequency meta-analysis with a 95% CI. We analyzed bias with the STROBE statement.
Of the 106 papers initially retrieved, four met the inclusion criteria. Vascular and urinary tract complications were reported in 19% and 15%, respectively. The overall patient survival was 92% 95%CI (88% to 95%), I2 = 0%, and the overall graft survival was 88% 95 CI (83% to 91%), I2 = 0%.
Our analysis showed a high survival rate in patients and kidney grafts after orthotopic kidney transplantation, with a similar complication rate compared to a heterotopic kidney transplant.
确定接受原位肾移植患者的移植物和患者生存率以及不良事件。
我们进行了一项系统评价和荟萃分析。我们检索了自数据库建立以来至目前的Medline、Embase和Central数据库。我们纳入了对接受原位肾移植患者的观察性研究。主要结局为患者总体生存率和移植物生存率。我们采用95%置信区间进行频率荟萃分析合并信息。我们依据STROBE声明分析偏倚。
在最初检索的106篇论文中，4篇符合纳入标准。血管和尿路并发症的报告发生率分别为19%和15%。患者总体生存率为92%，95%置信区间（88%至95%），I² = 0%；移植物总体生存率为88%，95%置信区间（83%至91%），I² = 0%。
我们的分析表明，原位肾移植后患者和肾移植物的生存率较高，与异位肾移植相比，并发症发生率相似。
