Yu Siyu, Ji Guang, Zhang Li
Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2022 Oct 24;13:1057829. doi: 10.3389/fphar.2022.1057829. eCollection 2022.
The tumor suppressor p53 is the central hub of a molecular network, which controls cell proliferation and death, and also plays an important role in the occurrence and development of liver fibrosis. The abundant post-translational processing and modification endow the functional diversity of p53. Considering the relationship between p53 and liver fibrosis, drug intervention targeting p53 or management of p53 regulation might be effective strategies to treat liver fibrosis. Here, we systematically discuss the regulation of p53 in different liver cells (hepatocytes, immune cells, HSCs, ) and the role of p53 in the development of liver fibrosis, and propose possible interventions to prevent the pathogenic processes of liver fibrosis.
肿瘤抑制因子p53是一个分子网络的核心枢纽，该网络控制细胞增殖和死亡，并且在肝纤维化的发生和发展中也起着重要作用。丰富的翻译后加工和修饰赋予了p53功能多样性。考虑到p53与肝纤维化之间的关系，针对p53的药物干预或对p53调控的管理可能是治疗肝纤维化的有效策略。在此，我们系统地讨论了p53在不同肝细胞（肝细胞、免疫细胞、肝星状细胞）中的调控以及p53在肝纤维化发展中的作用，并提出了预防肝纤维化致病过程的可能干预措施。
