Tang Yang, Gong Guidong, He Xianglian, Dai Mengyuan, Chen Mei, Wang Bo, Wang Yajie, Wang Xiaoling, Guo Junling
BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan, 610065, China.
National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, Sichuan, 610065, China.
Adv Healthc Mater. 2023 Feb;12(5):e2201578. doi: 10.1002/adhm.202201578. Epub 2022 Nov 24.
The development of bioadhesives is an important, yet challenging task as seemingly mutually exclusive properties need to be combined in one material, that is, strong adhesion, water resistance, and high biocompatibility. Here, a biocompatible and biodegradable protein-based bioadhesive patch (PBP) with high adhesion strength and low immunogenic response is reported. PBP exists as a strong adhesion for biological surfaces, which is higher than some conventional bioadhesives (i.e., polyethylene glycol and fibrin). Robust adhesion and strength are realized through the removal of interfacial water and fast formation of multiple supramolecular interactions induced by metal ions. The PBP's high biocompatibility is evaluated and immunogenic response in vitro and in vivo is neglected. The strong adhesion on soft biological tissues qualifies the PBP as biomedical glue outperforming some commercial products for applications in hemostasis performance, accelerated wound healing, and sealing of defected organs, anticipating to be useful as a tissue adhesive and sealant.
生物粘合剂的研发是一项重要但具有挑战性的任务，因为需要将看似相互排斥的特性结合在一种材料中，即强粘附性、耐水性和高生物相容性。在此，报道了一种具有高粘附强度和低免疫原性反应的生物相容性和可生物降解的蛋白质基生物粘合剂贴片（PBP）。PBP对生物表面具有很强的粘附力，高于一些传统生物粘合剂（即聚乙二醇和纤维蛋白）。通过去除界面水和金属离子诱导快速形成多种超分子相互作用，实现了强大的粘附力和强度。对PBP的高生物相容性进行了评估，其在体外和体内的免疫原性反应可忽略不计。PBP对柔软生物组织的强粘附性使其成为一种生物医学胶水，在止血性能、加速伤口愈合和封闭受损器官方面优于一些商业产品，有望用作组织粘合剂和密封剂。
