Instituto de Investigación e Innovación Biomédica de Cadiz (INiBICA), Hospital Universitario 'Puerta del Mar', Universidad de Cadiz, 11009 Cadiz, Spain.
Department of Analytical Chemistry, Institute of Research on Electron Microscopy and Materials (IMEYMAT), Faculty of Sciences, Campus de Excelencia Internacional del Mar (CEIMAR), University of Cadiz, Campus Universitario de Puerto Real, Polígono del Río San Pedro S/N, Puerto Real, 11510 Cadiz, Spain.
Biosensors (Basel). 2022 Oct 25;12(11):919. doi: 10.3390/bios12110919.
Monitoring of lactate is spreading from the evident clinical environment, where its role as a biomarker is notorious, to the agrifood ambit as well. In the former, lactate concentration can serve as a useful indicator of several diseases (e.g., tumour development and lactic acidosis) and a relevant value in sports performance for athletes, among others. In the latter, the spotlight is placed on the food control, bringing to the table meaningful information such as decaying product detection and stress monitoring of species. No matter what purpose is involved, electrochemical (bio)sensors stand as a solid and suitable choice. However, for the time being, this statement seems to be true only for discrete measurements. The reality exposes that real and continuous lactate monitoring is still a troublesome goal. In this review, a critical overview of electrochemical lactate (bio)sensors for clinical and agrifood situations is performed. Additionally, the transduction possibilities and different sensor designs approaches are also discussed. The main aim is to reflect the current state of the art and to indicate relevant advances (and bottlenecks) to keep in mind for further development and the final achievement of this highly worthy objective.
乳酸监测不仅在明显的临床环境中得到广泛应用，其作为生物标志物的作用已广为人知，而且在农业食品领域也得到了广泛应用。在前者中，乳酸浓度可以作为几种疾病（如肿瘤发展和乳酸性酸中毒）的有用指标，以及运动员运动表现的相关指标。在后者中，重点放在食品控制上，可以提供有意义的信息，如检测产品变质和监测物种压力。无论涉及到什么目的，电化学（生物）传感器都是一个坚实且合适的选择。然而，目前来看，这种说法似乎只适用于离散测量。现实情况表明，真正的连续乳酸监测仍然是一个棘手的目标。在这篇综述中，对用于临床和农业食品情况的电化学乳酸（生物）传感器进行了批判性的概述。此外，还讨论了转换的可能性和不同的传感器设计方法。主要目的是反映当前的技术水平，并指出进一步发展和最终实现这一非常有价值目标需要注意的相关进展（和瓶颈）。
Zotero 插件
