Hu Wei-Syun, Chen Tung-Sheng, Cheang Ka-Hung, Liao Wei-Yu, Chang Chin-Hsien
School of Medicine, College of Medicine, China Medical University, Taichung 40042, Taiwan.
Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung 40447, Taiwan.
J Cardiovasc Dev Dis. 2022 Nov 7;9(11):381. doi: 10.3390/jcdd9110381.
Cardiomyopathy is one of the complications associated with diabetes. Due to its high prevalence, diabetic cardiomyopathy has become an urgent issue for diabetic patients. Various pathological signals are related to diabetic cardiomyopathy progress, including inflammasome. Mesenchymal stem cell transplantation is full of potential for the treatment of diabetic cardiomyopathy because of stem cell cardiac regenerative capability. This study investigates whether mesenchymal stem cell transplantation shows therapeutic effects on diabetic cardiomyopathy through inflammasome signaling regulation.
Wistar male rats were divided into three groups including Sham, T1DM (rats with type 1 diabetes) and T1DM + WJSC (T1DM rats receiving 1 × 10 stem cells per rat).
Compared to the Sham, experimental results indicated that several pathological conditions can be observed in heart tissues with T1DM, including structural change, fibrosis, oxidative stress elevation and inflammasome related protein expression. All of these pathological conditions were significantly improved in T1DM rats receiving mesenchymal stem cell transplantation (T1DM + WJSC). Furthermore, the experimental findings suggest that mesenchymal stem cell transplantation exerted antioxidant protein expression in diabetic heart tissues, resulting in a decrease in oxidative stress and inflammasome signaling blockage.
These findings imply that mesenchymal stem cell transplantation shows therapeutic effects on diabetic cardiomyopathy through inflammasome regulation induced by oxidative stress.
心肌病是糖尿病相关并发症之一。由于其高患病率，糖尿病性心肌病已成为糖尿病患者面临的紧迫问题。多种病理信号与糖尿病性心肌病的进展相关，包括炎性小体。间充质干细胞移植因其干细胞心脏再生能力而在糖尿病性心肌病治疗方面极具潜力。本研究调查间充质干细胞移植是否通过炎性小体信号调节对糖尿病性心肌病具有治疗作用。
将雄性Wistar大鼠分为三组，包括假手术组、1型糖尿病（T1DM）组和T1DM + WJSC组（每只大鼠接受1×10个干细胞的T1DM大鼠）。
与假手术组相比，实验结果表明，T1DM组心脏组织中可观察到多种病理状况，包括结构改变、纤维化、氧化应激升高和炎性小体相关蛋白表达。在接受间充质干细胞移植的T1DM大鼠（T1DM + WJSC）中，所有这些病理状况均得到显著改善。此外，实验结果表明，间充质干细胞移植可使糖尿病心脏组织中抗氧化蛋白表达增加，从而降低氧化应激并阻断炎性小体信号传导。
这些发现表明，间充质干细胞移植通过氧化应激诱导的炎性小体调节对糖尿病性心肌病具有治疗作用。
