Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Korea.
Department of Medical Nutrition, Kyung Hee University, Yongin 17104, Korea.
Mar Drugs. 2022 Oct 30;20(11):685. doi: 10.3390/md20110685.
For this research article, we investigated the protective effects of enzyme-treated caviar powder extract (CV) in ultraviolet B (UVB)-irradiated hairless mice and keratinocytes by confirming moisturizing-related factors and elasticity-related factors. UVB irradiation induced wrinkle formation, dehydration, oxidative stress, and inflammation in the dorsal skin of mice; however, these were suppressed in the CV-supplemented groups in UVB-irradiated hairless mice. Furthermore, in UVB-irradiated keratinocytes, CV treatment increased the antioxidant enzyme activities and the levels of sphingomyelin and hyaluronic acid and decreased the production of pro-inflammatory cytokines and the expression of IkB-α and p65 phosphorylation. These findings indicate that CV can directly protect keratinocytes against UVB irradiation-induced oxidative stress and inflammation. Therefore, we suggest that CV can protect against UVB-induced skin photoaging. Therefore, we suggest that caviar is effective for skin health by preventing UVB-induced skin photoaging.
本研究通过确认保湿相关因子和弹性相关因子，调查了酶处理过的鱼子酱粉末提取物 (CV) 在紫外线 B (UVB) 照射无毛小鼠和角质细胞中的保护作用。UVB 照射诱导小鼠背部皮肤产生皱纹、脱水、氧化应激和炎症；然而，在补充 CV 的小鼠中，这些在 UVB 照射下得到了抑制。此外，在 UVB 照射的角质细胞中，CV 处理增加了抗氧化酶活性以及神经酰胺和透明质酸的水平，减少了促炎细胞因子的产生和 IkB-α 和 p65 磷酸化的表达。这些发现表明 CV 可以直接保护角质细胞免受 UVB 照射诱导的氧化应激和炎症。因此，我们认为 CV 可以预防 UVB 诱导的皮肤光老化。因此，我们认为鱼子酱通过预防 UVB 诱导的皮肤光老化对皮肤健康有效。
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