Nowowiejska Julia, Baran Anna, Flisiak Iwona
Department of Dermatology and Venereology, Medical University of Bialystok, 15-540 Bialystok, Poland.
Metabolites. 2022 Oct 22;12(11):1008. doi: 10.3390/metabo12111008.
Lichen planus (LP) is a dermatosis without a fully understood etiopathogenesis, the frequency of which is estimated to be less than 1% among the population. LP may involve the glabrous skin, mucosal membranes, scalp, nails and genital area. Nowadays, there are reports of its association with lipid homeostasis aberrations. In this review, we present the contemporary view of this matter. Dyslipidemia, especially hypertriglyceridemia, seems to be an actual problem in this group of patients, and along with abnormal arterial vessel parameters, indicates an increased risk of atherosclerosis in these subjects. Dermatologists should be attentive to this relationship and aware that the patients may develop different metabolic complications. More studies are required to establish clear guidelines on the management of lipid aberrations in lichen planus.
扁平苔藓（LP）是一种病因发病机制尚未完全明确的皮肤病，据估计其在人群中的发病率低于1%。LP可累及光滑皮肤、黏膜、头皮、指甲和生殖器部位。如今，有关于其与脂质稳态异常相关的报道。在本综述中，我们阐述了对此问题的当代观点。血脂异常，尤其是高甘油三酯血症，似乎是这类患者中的一个实际问题，并且与异常的动脉血管参数一起，表明这些受试者患动脉粥样硬化的风险增加。皮肤科医生应关注这种关系，并意识到患者可能会出现不同的代谢并发症。需要更多研究来制定关于扁平苔藓脂质异常管理的明确指南。
