CoMutDB：癌症中体细胞突变共发生的全景。
CoMutDB: the landscape of somatic mutation co-occurrence in cancers.
机构信息
Department of Internal Medicine, Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM 87109, USA.
Department of Computer Science, University of South Carolina, Columbia, SC, 29201, USA.
出版信息
Bioinformatics. 2023 Jan 1;39(1). doi: 10.1093/bioinformatics/btac725.
MOTIVATION
Somatic mutation co-occurrence has been proven to have a profound effect on tumorigenesis. While some studies have been conducted on co-mutations, a centralized resource dedicated to co-mutations in cancer is still lacking.
RESULTS
Using multi-omics data from over 30 000 subjects and 1747 cancer cell lines, we present the Cancer co-mutation database (CoMutDB), the most comprehensive resource devoted to describing cancer co-mutations and their characteristics.
AVAILABILITY AND IMPLEMENTATION
The data underlying this article are available in the online database CoMutDB: http://www.innovebioinfo.com/Database/CoMutDB/Home.php.
动机
体细胞突变的共同发生已被证明对肿瘤发生有深远的影响。虽然已经有一些关于共突变的研究，但专门针对癌症共突变的集中资源仍然缺乏。
结果
利用来自 30000 多个个体和 1747 个癌细胞系的多组学数据，我们展示了癌症共突变数据库（CoMutDB），这是最全面的用于描述癌症共突变及其特征的资源。
可用性和实现
本文所依据的数据可在在线数据库 CoMutDB 中获得：http://www.innovebioinfo.com/Database/CoMutDB/Home.php。
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