利用癌症生物信息学数据库中的体细胞突变目录进行数据挖掘。
Data mining using the Catalogue of Somatic Mutations in Cancer BioMart.
机构信息
Cancer Genome Project, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.
出版信息
Database (Oxford). 2011 May 23;2011:bar018. doi: 10.1093/database/bar018. Print 2011.
Catalogue of Somatic Mutations in Cancer (COSMIC) (http://www.sanger.ac.uk/cosmic) is a publicly available resource providing information on somatic mutations implicated in human cancer. Release v51 (January 2011) includes data from just over 19,000 genes, 161,787 coding mutations and 5573 gene fusions, described in more than 577,000 tumour samples. COSMICMart (COSMIC BioMart) provides a flexible way to mine these data and combine somatic mutations with other biological relevant data sets. This article describes the data available in COSMIC along with examples of how to successfully mine and integrate data sets using COSMICMart. DATABASE URL: http://www.sanger.ac.uk/genetics/CGP/cosmic/biomart/martview/.
癌症体细胞突变目录（COSMIC）（http://www.sanger.ac.uk/cosmic）是一个公开的资源，提供了与人类癌症相关的体细胞突变信息。版本 v51（2011 年 1 月）包含了来自 19000 多个基因、161787 个编码突变和 5573 个基因融合的数据，这些数据描述了超过 577000 个肿瘤样本。COSMICMart（COSMIC BioMart）提供了一种灵活的方式来挖掘这些数据，并将体细胞突变与其他生物学相关数据集进行组合。本文描述了 COSMIC 中可用的数据，并提供了如何使用 COSMICMart 成功挖掘和整合数据集的示例。数据库 URL：http://www.sanger.ac.uk/genetics/CGP/cosmic/biomart/martview/。
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