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螺旋木苷A - E，来自[植物名称]叶子的异常大环和酚类糖苷及其对葡萄糖摄取的刺激作用 。 需注意，原文中“from the Leaves of ”这里遗漏了具体植物名称。

Heliciopsides A-E, Unusual Macrocyclic and Phenolic Glycosides from the Leaves of and Their Stimulation of Glucose Uptake.

作者信息

Ryu Byeol, Park Eun-Jin, Doan Thi-Phuong, Cho Hyo-Moon, An Jin-Pyo, Pham Thi-Linh-Giang, Pham Ha-Thanh-Tung, Oh Won-Keun

机构信息

Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea.

Department of Botany, Hanoi University of Pharmacy, Hanoi 000084, Vietnam.

出版信息

Pharmaceuticals (Basel). 2022 Oct 25;15(11):1315. doi: 10.3390/ph15111315.

DOI:10.3390/ph15111315
PMID:36355487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9695999/
Abstract

Ten phenolic constituents, including three new macrocyclic glycosides (-), a new phenolic glycoside (), a new biphenyl glycoside (), and five known compounds (, -), were isolated from a 70% MeOH extract of the leaves of by liquid chromatography-tandem mass spectrometry (LC-MS/MS)-guided molecular networking. The chemical structures of new compounds -, and were established based on comprehensive spectroscopic data analysis, including 1D and 2D NMR and HRESIMS techniques. All isolated compounds (-) were evaluated for their stimulation of glucose uptake in differentiated 3T3-L1 adipocytes using 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-d-glucose (2-NBDG) as a fluorescent glucose analog. Compounds , and showed stimulatory effects on the uptake of 2-NBDG in 3T3-L1 adipocyte cells. Among them, compounds and activated the AMPK signaling pathway in differentiated C2C12 myoblasts.

摘要

通过液相色谱-串联质谱（LC-MS/MS）引导的分子网络，从[植物名称]叶片的70%甲醇提取物中分离出10种酚类成分，包括3种新的大环糖苷（-）、1种新的酚苷（）、1种新的联苯苷（）和5种已知化合物（，-）。基于包括一维和二维核磁共振以及高分辨电喷雾电离质谱技术在内的综合光谱数据分析，确定了新化合物-、和的化学结构。使用2-脱氧-2-[(7-硝基-2,1,3-苯并恶二唑-4-基)氨基]-d-葡萄糖（2-NBDG）作为荧光葡萄糖类似物，对所有分离出的化合物（-）在分化的3T3-L1脂肪细胞中刺激葡萄糖摄取的能力进行了评估。化合物、和对3T3-L1脂肪细胞中2-NBDG的摄取显示出刺激作用。其中，化合物和在分化的C2C12成肌细胞中激活了AMPK信号通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/b89638a50e5f/pharmaceuticals-15-01315-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/4e821ef969ff/pharmaceuticals-15-01315-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/3513921212e1/pharmaceuticals-15-01315-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/2ed66ecb8012/pharmaceuticals-15-01315-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/481450675178/pharmaceuticals-15-01315-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/b89638a50e5f/pharmaceuticals-15-01315-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/4e821ef969ff/pharmaceuticals-15-01315-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/3513921212e1/pharmaceuticals-15-01315-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/2ed66ecb8012/pharmaceuticals-15-01315-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/481450675178/pharmaceuticals-15-01315-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b24/9695999/b89638a50e5f/pharmaceuticals-15-01315-g005.jpg

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