Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
National Laboratory for Scientific Computing, Petrópolis, Brazil.
PLoS One. 2022 Nov 10;17(11):e0275837. doi: 10.1371/journal.pone.0275837. eCollection 2022.
We review a collection of published renal epithelial transport models, from which we build a consistent and reusable mathematical model able to reproduce many observations and predictions from the literature. The flexible modular model we present here can be adapted to specific configurations of epithelial transport, and in this work we focus on transport in the proximal convoluted tubule of the renal nephron. Our mathematical model of the epithelial proximal convoluted tubule describes the cellular and subcellular mechanisms of the transporters, intracellular buffering, solute fluxes, and other processes. We provide free and open access to the Python implementation to ensure our multiscale proximal tubule model is accessible; enabling the reader to explore the model through setting their own simulations, reproducibility tests, and sensitivity analyses.
我们回顾了一系列已发表的肾脏上皮细胞转运模型，从中构建了一个一致且可重复使用的数学模型，该模型能够再现文献中的许多观察结果和预测。我们在这里提出的灵活模块化模型可以适用于上皮转运的特定构型，在这项工作中，我们专注于肾脏肾单位的近曲小管中的转运。我们的上皮近曲小管的数学模型描述了转运蛋白、细胞内缓冲、溶质通量和其他过程的细胞和亚细胞机制。我们提供了 Python 实现的免费和开放访问，以确保我们的多尺度近曲小管模型是可访问的；使读者能够通过设置自己的模拟、可重复性测试和敏感性分析来探索模型。
