Department of Toxicology and Sanitary Chemistry, School of Public Health, and Beijing Key Laboratory of Environment Toxicology, Capital Medical University, Beijing 100069, P. R. China.
Key Laboratory of Environmental Medicine Engineering Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, P. R. China.
Langmuir. 2022 Nov 22;38(46):14326-14334. doi: 10.1021/acs.langmuir.2c02388. Epub 2022 Nov 10.
Combination chemotherapy is recognized as a vital medical treatment for cancer, but it has not achieved clinical ideal effects of combination therapy. Herein, we designed a supramolecular combination chemotherapy strategy based on cucurbit[8]uril (CB[8]), which can be facilely assembled into dual platinum drugs. Interestingly, employing the CB[8] carrier led to a greater than 10-fold intracellular Pt content compared to that of dual drugs at 4 h, and the CB[8] complex (CLE) can enhance the infiltration of platinum drugs in colorectal tumor cells tremendously. The platinum drugs can be released from CLE through consuming more tumor biomarker spermidine. Through analyzing the nanomechanical property of the colorectal tumor cellular surface by bioscope AFM, it was revealed that CLE modified the property by decreasing the adhesion and increasing the stiffness. This study provided a facile and sensitive strategy for improving combination chemotherapy by supramolecular materials.
联合化疗被认为是癌症的重要治疗方法，但尚未达到联合治疗的临床理想效果。在此，我们设计了一种基于葫芦[8]脲（CB[8]）的超分子联合化疗策略，可将其简便地组装成双铂药物。有趣的是，与 4 小时时的两种药物相比，使用 CB[8]载体使细胞内的 Pt 含量增加了 10 倍以上，而 CB[8]配合物（CLE）可极大地增强铂类药物在结直肠肿瘤细胞中的渗透。铂类药物可以通过消耗更多的肿瘤生物标志物精脒从 CLE 中释放出来。通过分析生物显微镜 AFM 对结直肠肿瘤细胞表面的纳米力学特性，发现 CLE 通过降低黏附力和增加硬度来改变其性质。这项研究为通过超分子材料提高联合化疗效果提供了一种简便、灵敏的策略。
