Pezzanite Lynn M, Chow Lyndah, Strumpf Alyssa, Johnson Valerie, Dow Steven W
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, The Ohio State University, Columbus, OH 43210, USA.
Vet Sci. 2022 Nov 4;9(11):610. doi: 10.3390/vetsci9110610.
Antimicrobial resistance and biofilm formation both present challenges to treatment of bacterial infections with conventional antibiotic therapy and serve as the impetus for development of improved therapeutic approaches. Mesenchymal stromal cell (MSC) therapy exerts an antimicrobial effect as demonstrated in multiple acute bacterial infection models. This effect can be enhanced by pre-conditioning the MSC with Toll or Nod-like receptor stimulation, termed activated cellular therapy (ACT). The purpose of this review is to summarize the current literature on mechanisms of antimicrobial activity of MSC with emphasis on enhanced effects through receptor agonism, and data supporting use of ACT in treatment of bacterial infections in veterinary species including dogs, cats, and horses with implications for further treatment applications. This review will advance the field's understanding of the use of activated antimicrobial cellular therapy to treat infection, including mechanisms of action and potential therapeutic applications.
抗菌耐药性和生物膜形成对传统抗生素治疗细菌感染均构成挑战，并推动了改进治疗方法的发展。间充质基质细胞（MSC）疗法在多种急性细菌感染模型中已证明具有抗菌作用。通过用Toll样受体或Nod样受体刺激对MSC进行预处理可增强这种作用，称为活化细胞疗法（ACT）。本综述的目的是总结当前关于MSC抗菌活性机制的文献，重点是通过受体激动作用增强的效果，以及支持ACT用于治疗犬、猫和马等兽医物种细菌感染的数据，并探讨其进一步的治疗应用。本综述将促进该领域对活化抗菌细胞疗法治疗感染的理解，包括作用机制和潜在的治疗应用。
