Arifka Mia, Wilar Gofarana, Elamin Khaled M, Wathoni Nasrul
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
Polymers (Basel). 2022 Mar 17;14(6):1218. doi: 10.3390/polym14061218.
Secretomes of mesenchymal stem cells (MSCs) have been successfully studied in preclinical models for several biomedical applications, including tissue engineering, drug delivery, and cancer therapy. Hydrogels are known to imitate a three-dimensional extracellular matrix to offer a friendly environment for stem cells; therefore, hydrogels can be used as scaffolds for tissue construction, to control the distribution of bioactive compounds in tissues, and as a secretome-producing MSC culture media. The administration of a polymeric hydrogel-based MSC secretome has been shown to overcome the fast clearance of the target tissue. In vitro studies confirm the bioactivity of the secretome encapsulated in the gel, allowing for a controlled and sustained release process. The findings reveal that the feasibility of polymeric hydrogels as MSC -secretome delivery systems had a positive influence on the pace of tissue and organ regeneration, as well as an enhanced secretome production. In this review, we discuss the widely used polymeric hydrogels and their advantages as MSC secretome delivery systems in biomedical applications.
间充质干细胞（MSCs）的分泌组已在多种生物医学应用的临床前模型中得到成功研究，包括组织工程、药物递送和癌症治疗。众所周知，水凝胶可模拟三维细胞外基质，为干细胞提供适宜的环境；因此，水凝胶可用作组织构建的支架，用于控制生物活性化合物在组织中的分布，还可作为分泌组产生的MSC培养基。基于聚合物水凝胶的MSC分泌组给药已被证明可克服靶组织的快速清除。体外研究证实了包裹在凝胶中的分泌组的生物活性，实现了可控的持续释放过程。研究结果表明，聚合物水凝胶作为MSC分泌组递送系统的可行性对组织和器官再生的速度有积极影响，同时还能提高分泌组的产量。在这篇综述中，我们讨论了在生物医学应用中广泛使用的聚合物水凝胶及其作为MSC分泌组递送系统的优势。
