Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Vet Clin North Am Equine Pract. 2023 Dec;39(3):565-578. doi: 10.1016/j.cveq.2023.06.005. Epub 2023 Jul 11.
Increasing antimicrobial resistance in veterinary practice has driven the investigation of novel therapeutic strategies including regenerative and biologic therapies to treat bacterial infection. Integration of biological approaches such as platelet lysate and mesenchymal stromal cell (MSC) therapy may represent adjunctive treatment strategies for bacterial infections that minimize systemic side effects and local tissue toxicity associated with traditional antibiotics and that are not subject to antibiotic resistance. In this review, we will discuss mechanisms by which biological therapies exert antimicrobial effects, as well as potential applications and challenges in clinical implementation in equine practice.
兽医实践中抗菌药物耐药性的增加推动了对新型治疗策略的研究，包括再生和生物疗法来治疗细菌感染。血小板裂解液和间充质基质细胞（MSC）治疗等生物方法的整合可能代表了治疗细菌感染的辅助治疗策略，可以最大程度减少与传统抗生素相关的全身副作用和局部组织毒性，并且不受抗生素耐药性的影响。在这篇综述中，我们将讨论生物疗法发挥抗菌作用的机制，以及在马科动物临床应用中的潜在应用和挑战。
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