Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), KAIST Institute for BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, Daejeon 34141, Republic of Korea.
Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, Daejeon 34141, Republic of Korea; Systems Biology and Medicine Laboratory, Department of Chemical and Biomolecular Engineering, KAIST, Daejeon 34141, Republic of Korea; BioProcess Engineering Research Center and BioInformatics Research Center, KAIST, Daejeon 34141, Republic of Korea.
Trends Biotechnol. 2023 Jun;41(6):798-816. doi: 10.1016/j.tibtech.2022.10.005. Epub 2022 Nov 7.
Sustainable production of chemicals and materials from renewable non-food biomass using biorefineries has become increasingly important in an effort toward the vision of 'net zero carbon' that has recently been pledged by countries around the world. Systems metabolic engineering has allowed the efficient development of microbial strains overproducing an increasing number of chemicals and materials, some of which have been translated to industrial-scale production. Fermentation is one of the key processes determining the overall economics of bioprocesses, but has recently been attracting less research attention. In this Review, we revisit and discuss factors affecting the competitiveness of bacterial fermentation in connection to strain development by systems metabolic engineering. Future perspectives for developing efficient fermentation processes are also discussed.
利用生物炼制厂从可再生非食用生物质中可持续生产化学品和材料，在全球各国最近承诺的“净零碳”愿景方面变得越来越重要。系统代谢工程使得高效开发微生物菌株生产越来越多的化学品和材料成为可能，其中一些已经转化为工业规模的生产。发酵是决定生物工艺整体经济性的关键工艺之一，但最近受到的研究关注较少。在这篇综述中，我们重新审视和讨论了影响通过系统代谢工程进行菌株开发的细菌发酵竞争力的因素。还讨论了开发高效发酵工艺的未来展望。
