Metabolic and Biomolecular Engineering National Research Laboratory and Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Institute for the BioCentury and KAIST Institute for Artificial Intelligence, KAIST, Daejeon 34141, Republic of Korea; BioProcess Engineering Research Center and BioInformatics Research Center, KAIST, Daejeon 34141, Republic of Korea.
Metabolic and Biomolecular Engineering National Research Laboratory and Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Institute for the BioCentury and KAIST Institute for Artificial Intelligence, KAIST, Daejeon 34141, Republic of Korea.
Curr Opin Biotechnol. 2022 Oct;77:102760. doi: 10.1016/j.copbio.2022.102760. Epub 2022 Jul 28.
Increased awareness of the environmental and health concerns of consuming chemically synthesized products has led to a rising demand for natural products that are greener and more sustainable. Despite their importance, however, industrial-scale production of natural products has been challenging due to the low yield and high cost of the bioprocesses. To cope with this problem, systems metabolic engineering has been employed to efficiently produce natural products from renewable biomass. Here, we review the recent systems metabolic engineering strategies employed for enhanced production of value-added natural products, together with accompanying examples. Particular focus is set on systems-level engineering and cell physiology engineering strategies. Future perspectives are also discussed.
人们越来越意识到消费化学合成产品所带来的环境和健康问题，因此对绿色环保且可持续的天然产品的需求也与日俱增。然而，尽管天然产品非常重要，但由于生物工艺的产量低、成本高，其工业化生产一直具有挑战性。为了解决这个问题，人们采用了系统代谢工程来有效地从可再生生物质中生产天然产物。在这里，我们综述了最近用于提高有价值天然产物生产的系统代谢工程策略，并附有相应的实例。特别关注的是系统级工程和细胞生理学工程策略。同时还讨论了未来的展望。
