Bezlotoxumab in Patients with a Primary Infection: A Literature Review.

BACKGROUND

Nowadays, one of the main issues in the management of infection (CDI) is the high rate of recurrences (rCDI), causing increased mortality and higher health care costs.

OBJECTIVES

To assess the available evidence on the use of bezlotoxumab for the prevention of rCDI during a first CDI episode.

METHODS

Published articles on bezlotoxumab during a primary CDI episode were identified through computerized literature searches with the search terms [(bezlotoxumab) AND (CDI) OR ( infection)] using PubMed and by reviewing the references of retrieved articles. PubMed was searched until 31 August 2022.

RESULTS

Eighty-eight studies were identified as published from December 2014 to June 2022. Five studies were included in this study, one was a phase III clinical trial and four were sub-analyses or extensions of the previous phase III clinical trial. In the phase III clinical trial, the subgroup analysis on the included primary CDI patients showed that 13.5% of patients receiving bezlotoxumab had an rCDI, whilst 20.9% of patients in the placebo group had an rCDI at the twelve weeks follow-up (absolute difference: -7.4).

CONCLUSIONS

Bezlotoxumab administration during the standard of care antibiotic therapy is effective and safe in reducing the rate of rCDI. Despite its high cost, evidence suggests considering bezlotoxumab in patients with a primary CDI episode. Further studies are needed to assess the benefit in specific subgroups of primary CDI patients and to define the risk factors to guide bezlotoxumab use.