Sudakov Sergey K, Bogdanova Natalia G, Nazarova Galina A
P.K. Anokhin Research Institute of Normal Physiology, 125315 Moscow, Russia.
Biology (Basel). 2022 Nov 2;11(11):1606. doi: 10.3390/biology11111606.
The aim of this work was to study whether epigenetic events at conception influence the formation of behavioral features found in adult rats. First generational inheritance of activity level, anxiety like behavior, and learning ability was studied. To separate genetic and non-genetic inheritance, mating of males and females with average motor activity was carried out in the presence anesthetized or conscious males with high or low activity. Our results show that offspring of parents who mated in the presence of males with a high motor activity were significantly more active than offspring of parents that were paired in the presence of males with low activity. Anxiety like behavior and learning ability were not inherited in this way. It is possible that the phenomenon we discovered is important for maintaining a certain level of activity of specific populations of animals. It counteracts natural selection, which should lead to a constant increase in the activity of animals.
这项工作的目的是研究受孕时的表观遗传事件是否会影响成年大鼠行为特征的形成。研究了第一代活动水平、焦虑样行为和学习能力的遗传情况。为了区分遗传和非遗传遗传，在麻醉或清醒的高活动或低活动雄性大鼠存在的情况下，让平均运动活动水平的雄性和雌性大鼠进行交配。我们的结果表明，在高活动雄性大鼠存在的情况下交配的亲本所生的后代比在低活动雄性大鼠存在的情况下配对的亲本所生的后代明显更活跃。焦虑样行为和学习能力并非以这种方式遗传。我们发现的这种现象可能对于维持特定动物群体的一定活动水平很重要。它抵消了自然选择，而自然选择会导致动物活动不断增加。
