Caudet Jana, Trelis María, Cifre Susana, Tapia Gabriela, Soriano José M, Rodrigo Regina, Merino-Torres Juan F
Department of Endocrinology and Nutrition, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain.
Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, Health Research Institute Hospital La Fe-University of Valencia, 46026 Valencia, Spain.
Antioxidants (Basel). 2022 Oct 23;11(11):2090. doi: 10.3390/antiox11112090.
The diagnosis of obesity comprises subjects with totally different phenotypes and metabolic profiles. Systemic inflammation and oxidative stress derived from the white adipose tissue are suggested as the link between this disease and the development of insulin resistance and metabolic comorbidities. The presence of unicellular eukaryotic parasites colonizing the human gut ecosystem is a common circumstance, and yet their influence on the inflammatory and redox status of the obese host has not been assessed. Herein, a set of inflammatory and redox biomarkers were assessed together with a parasitological analysis of 97 severely obese subjects. Information was also collected on insulin resistance and on the antioxidant composition of the diet. The global prevalence of intestinal unicellular parasites was 49.5%, with sp. the most prevalent protozoan found (42.3%). Colonized subjects displayed a higher total antioxidant capacity and a trend towards higher extracellular superoxide dismutase activity, regardless of their insulin resistance status, along with lower reduced glutathione/oxidized glutathione (GSH/GSSG) ratios in plasma in the insulin-resistant subgroup. No changes in malondialdehyde levels, or in inflammatory cytokines in plasma, were found in regard to the colonization status. In conclusion, enteric eukaryotic unicellular parasites may play an important role in modulating the antioxidant defenses of an obese host, thus could have beneficial effects with respect to the development of systemic metabolic disorders.
肥胖的诊断涵盖了具有完全不同表型和代谢特征的人群。源自白色脂肪组织的全身炎症和氧化应激被认为是这种疾病与胰岛素抵抗及代谢合并症发展之间的联系。单细胞真核寄生虫定殖于人类肠道生态系统是一种常见情况，但其对肥胖宿主炎症和氧化还原状态的影响尚未得到评估。在此，对97名严重肥胖受试者进行了一组炎症和氧化还原生物标志物评估以及寄生虫学分析。还收集了有关胰岛素抵抗和饮食抗氧化成分的信息。肠道单细胞寄生虫的总体患病率为49.5%，其中 种是最常见的原生动物（42.3%）。无论胰岛素抵抗状态如何，定殖受试者都表现出较高的总抗氧化能力以及细胞外超氧化物歧化酶活性升高的趋势，同时胰岛素抵抗亚组血浆中还原型谷胱甘肽/氧化型谷胱甘肽（GSH/GSSG）比值较低。在定殖状态方面，未发现丙二醛水平或血浆中炎症细胞因子有变化。总之，肠道真核单细胞寄生虫可能在调节肥胖宿主的抗氧化防御中发挥重要作用，因此可能对全身性代谢紊乱的发展具有有益影响。
