Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa 920-8641, Japan.
Int J Mol Sci. 2021 Dec 23;23(1):144. doi: 10.3390/ijms23010144.
Macrophages are present in most human tissues and have very diverse functions. Activated macrophages are usually divided into two phenotypes, M1 macrophages and M2 macrophages, which are altered by various factors such as microorganisms, tissue microenvironment, and cytokine signals. Macrophage polarity is very important for infections, inflammatory diseases, and malignancies; its management can be key in the prevention and treatment of diseases. In this review, we assess the current state of knowledge on macrophage polarity and report on its prospects as a therapeutic target.
巨噬细胞存在于大多数人体组织中，具有非常多样化的功能。激活的巨噬细胞通常分为两种表型，M1 巨噬细胞和 M2 巨噬细胞，它们受微生物、组织微环境和细胞因子信号等各种因素的影响而改变。巨噬细胞的极性对感染、炎症性疾病和恶性肿瘤非常重要；其调控可能是疾病预防和治疗的关键。在这篇综述中，我们评估了巨噬细胞极性的现有知识状态，并报告了将其作为治疗靶点的前景。
