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一例源于胆囊腺肌增生症的早期胆囊癌，醛脱氢酶1A1呈阳性

A Case of Early-Stage Gallbladder Cancer, Positive for ALDH1A1, Which Arose from Adenomyomatosis of the Gallbladder.

作者信息

Iwasa Yuhei, Iwata Keisuke, Okuno Mitsuru, Sugiyama Akihiko, Nishigaki Yoichi, Ohashi Yosuke, Tanaka Takuji, Iwashita Takuji, Shimizu Masahito, Tomita Eiichi

机构信息

Department of Gastroenterology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, Japan.

Department of Diagnostic Pathology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, Japan.

出版信息

Diagnostics (Basel). 2022 Nov 7;12(11):2721. doi: 10.3390/diagnostics12112721.

DOI:10.3390/diagnostics12112721
PMID:36359563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9689884/
Abstract

Adenomyomatosis (ADM) of the gallbladder is a condition characterized by the proliferation of Rokitansky-Aschoff sinus (RAS), in which the epithelium of the gallbladder extends into the muscular layer, causing a thickening of the gallbladder wall. Although ADM is generally considered not to be a precancerous lesion of gallbladder cancer, there are some reports of cases of gallbladder cancer from ADM. Therefore, the relationship between ADM and gallbladder cancer remains controversial. We herein report a case of early-stage gallbladder cancer, BilIN3 (high grade), arising from ADM that was positive for ALDH1A1, an important marker of stem cells and cancer stem cells.

摘要

胆囊腺肌增生症（ADM）是一种以罗-阿窦（RAS）增生为特征的疾病，其中胆囊上皮延伸至肌层，导致胆囊壁增厚。尽管ADM一般不被认为是胆囊癌的癌前病变，但有一些关于ADM发展为胆囊癌的病例报告。因此，ADM与胆囊癌之间的关系仍存在争议。我们在此报告一例源于ADM的早期胆囊癌，BilIN3（高级别），该病例中醛脱氢酶1A1（ALDH1A1）呈阳性，ALDH1A1是干细胞和癌症干细胞的重要标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/6cdbcb4a5f29/diagnostics-12-02721-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/393895a7e9d6/diagnostics-12-02721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/3033cff68d0d/diagnostics-12-02721-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/b033ae4c450d/diagnostics-12-02721-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/270c664502e0/diagnostics-12-02721-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/1a479462ad88/diagnostics-12-02721-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/6cdbcb4a5f29/diagnostics-12-02721-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/393895a7e9d6/diagnostics-12-02721-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/3033cff68d0d/diagnostics-12-02721-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/b033ae4c450d/diagnostics-12-02721-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/270c664502e0/diagnostics-12-02721-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/1a479462ad88/diagnostics-12-02721-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4a8f/9689884/6cdbcb4a5f29/diagnostics-12-02721-g006.jpg

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