Batyrova Gulnara, Tlegenova Zhenisgul, Kononets Victoria, Umarova Gulmira, Bazargaliyev Yerlan, Taskozhina Gulaim, Kereyeva Nurgul, Umarov Yeskendir
Department of Laboratory and Visual Diagnostics, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan.
Department of Internal Diseases No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe 030019, Kazakhstan.
Diagnostics (Basel). 2022 Nov 8;12(11):2734. doi: 10.3390/diagnostics12112734.
This study aimed to investigate the content of essential elements in the hair of unvaccinated residents of the Caspian region who recovered from COVID-19. This cross-sectional study involved 260 unvaccinated permanent residents of Mangistau oblast aged 18−60. The diagnosis and severity of COVID-19 were based on clinical signs and symptoms, laboratory data, R-graph results, and oxygen saturation by the Clinical Protocol of the Ministry of Health of the Republic of Kazakhstan. Inductively coupled plasma mass spectrometry determined the content of trace elements cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), iodine (I), manganese (Mn), selenium (Se), and zinc (Zn). The content of Cr (p < 0.05), Cu (p < 0.05), Fe (p < 0.001), I (p < 0.05), Mn (p < 0.001), and Zn (p < 0.05) in the hair of individuals who had a coronavirus infection was lower than those who did not have this infection. There were significantly higher levels of Cu (p < 0.05) in the hair of participants who had moderate or severe COVID-19 compared to those with mild forms. The results of multiple regression analysis showed that in the presence of a COVID-19 infection in a subject’s history, the content of Cr (0.871 (95% CI: 0.811; 0.936)), Cu (0.875 (95% CI: 0.803; 0.955)), Fe (0.745 (95% CI: 0.636; 0.873)), and Mn (0.642 (95%CI: 00.518; 0.795)) decreased in the hair. The data obtained indicate that past COVID-19 infections affect the trace element status of the inhabitants of the Caspian region of Kazakhstan.
本研究旨在调查里海地区未接种疫苗且已从新冠病毒感染中康复的居民头发中必需元素的含量。这项横断面研究涉及260名年龄在18至60岁之间、未接种疫苗的曼格斯套州常住居民。根据哈萨克斯坦共和国卫生部临床方案，通过临床症状、实验室数据、R图结果和血氧饱和度来诊断新冠病毒感染及其严重程度。采用电感耦合等离子体质谱法测定微量元素钴（Co）、铬（Cr）、铜（Cu）、铁（Fe）、碘（I）、锰（Mn）、硒（Se）和锌（Zn）的含量。感染新冠病毒的个体头发中Cr（p<0.05）、Cu（p<0.05）、Fe（p<0.001）、I（p<0.05）、Mn（p<0.001）和Zn（p<0.05）的含量低于未感染该病毒的个体。与轻症新冠患者相比，中度或重度新冠患者头发中的Cu含量显著更高（p<0.05）。多元回归分析结果表明，若研究对象有新冠病毒感染史，其头发中Cr（0.871（95%CI：0.811；0.936））、Cu（0.875（95%CI：0.803；0.955））、Fe（（0.745（95%CI：0.636；0.873））和Mn（0.642（95%CI：0.518；0.795））的含量会降低。所得数据表明，过去的新冠病毒感染会影响哈萨克斯坦里海地区居民的微量元素状况。
