免疫球蛋白聚集体定位于生发中心的结构要求。
The structural requirements for immunoglobulin aggregates to localize in germinal centres.
作者信息
Embling P H, Evans H, Guttierez C, Holborow E J, Johns P, Johnson P M, Papamichail M, Stanworth D R
出版信息
Immunology. 1978 Apr;34(4):781-6.
The capacity of non-heat-aggregated monoclonal human immunoglobulins of different classes, to localize in murine splenic germinal centres within 24 h of intravenous injection has been investigated. It has been shown that at least trimerization of polyclonal IgG must occur before any germinal centre trapping is manifest. Studies of complement fixation by these IgG preparations in vivo, together with studies of the germinal centre trapping of various monoclonal immunoglobulins, have indicated that the sole structural requirement for germinal centre localization of immunoglobulin aggregates is the ability to fix complement. Results suggest that immunoglobulin aggregates are transported to germinal centres via membrane C3 receptors of mobile cells, and then are released with loss of complement to become fixed to dendritic macrophages by a separate mechanism.
已对不同类别的非热聚集单克隆人免疫球蛋白在静脉注射后24小时内定位于小鼠脾脏生发中心的能力进行了研究。结果表明，在生发中心捕获现象出现之前，多克隆IgG至少必须发生三聚化。对这些IgG制剂在体内补体固定的研究，以及对各种单克隆免疫球蛋白生发中心捕获的研究表明，免疫球蛋白聚集体定位于生发中心的唯一结构要求是补体固定能力。结果提示，免疫球蛋白聚集体通过移动细胞的膜C3受体转运至生发中心，然后随着补体的丧失而释放，并通过一种独立机制固定于树突状巨噬细胞。
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